KCNJ3 抗体 (Extracellular)
-
- 抗原 See all KCNJ3 抗体
- KCNJ3 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3))
-
抗原表位
- Extracellular
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This KCNJ3 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)
- 原理
- A Mouse Monoclonal Antibody to GIRK1 (Kir3.1) Channel
- 特异性
- Extracellular loop
- 交叉反应
- 人, 小鼠
- 预测反应
- Kir3.1 from human,rat,mouse samples
- 产品特性
- Mouse Anti-GIRK1 (Kir3.1) (extracellular) Antibody (ABIN7043483 and ABIN7044555) is a highly specific mouse monoclonal antibody directed against an epitope of the human protein. The antibody can be used in western blot, and immunocytochemistry applications. It has been designed to recognize Kir3.1 from human, rat and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: Synthetic mapping to the extracellular loop of human GIRK1
- 克隆位点
- 3C3
- 亚型
- IgG1
- Top Product
- Discover our top product KCNJ3 Primary Antibody
-
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 279-501) antibody
KCNJ3 适用: 人, 小鼠, 猴 WB, IF, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3E11 unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 81-180) antibodyKCNJ3 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (Internal Region) antibodyKCNJ3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 350-487) antibodyKCNJ3 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (Center) antibodyKCNJ3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 151-200), (pSer185) antibodyKCNJ3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (Internal Region) antibodyKCNJ3 适用: 人, 小鼠, 大鼠, 猴, Cow, 豚鼠, 马, Pig, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (Ser685) antibodyKCNJ3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 361-410) antibodyKCNJ3 适用: 人, 小鼠, 大鼠, 猴, Cow, 豚鼠, 马, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 50-150) antibodyKCNJ3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Antigen preadsorption control: NA
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
- 抗原
- KCNJ3 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3))
- 别名
- KCNJ3 (KCNJ3 产品)
- 背景
-
KCNJ3, G protein-activated inward rectifier potassium channel 1,Kir3.1 (or G-protein regulated inward-rectifier K+ channel 1, GIRK1) is a member of the family of inward rectifying K+ channels. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.The family's topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels, the functional unit for the Kir channels is composed of four subunits that can assemble as either homo- or heterotetramers.Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis.Kir3.1 is a member of the Kir3.x subfamily that includes four members (Kir3.1- Kir3.4). The Kir3 family is characterized by the fact that the channels can be activated by neurotransmitters and other factors acting via the activation of G-protein coupled receptors. Binding of the corresponding ligand to the G-protein receptor induces the dissociation of Gα-GTP from the Gβγ dimer. The latter directly binds to Kir3 and activates the channel1,3.In the heart, Kir3.1 co-assembles with Kir3.4 to form the prototypical muscarinic-gated K+ channel KAch current, responsible for slowing the heart rate in response of parasympathetic stimulation2.In the brain, Kir3.1 co-assembles with Kir3.2 and mediates the inhibitory effects of many neurotransmitters including opioid, adrenergic, muscarinic, dopaminergic and γ-aminobutyric acid (GABA)1,3.A peptide toxin originating from the Apis mellifera bee venom, Tertiapin (#STT-250) was shown to be a potent blocker of Kir3.1 containing channels (8.6 nM for the Kir3.1/3.4 combination and 5.4 nM for the Kir3.1/3.2)4,5.
Alternative names: GIRK1 (Kir3.1), KCNJ3, G protein-activated inward rectifier potassium channel 1 - 基因ID
- 3760
- NCBI登录号
- NM_002239
- UniProt
- P48549
-
