KCNN1 抗体 (Intracellular)
Quick Overview for KCNN1 抗体 (Intracellular) (ABIN7043459)
抗原
See all KCNN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 75-93, Intracellular
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原理
- A Rabbit Polyclonal Antibody to KCNN1 (KCa2.1, SK1) Channel
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特异性
- Intracellular, N-terminal domain
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交叉反应
- 小鼠, 大鼠
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预测反应
- 19 amino acid residues identical, human - 12,Mouse - 17
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产品特性
- Anti-KCNN1 (KCa2.1, SK1) Antibody (ABIN7043459, ABIN7044948 and ABIN7044949) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize KCNN1 from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DRPGSGKPPTVSHRLGHRR corresponding to amino acid residues 75-93 of rat KCNN1
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亚型
- IgG
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anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 1 (KCNN1) (Internal Region) antibody
KCNN1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 1 (KCNN1) antibodyKCNN1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 1 (KCNN1) (AA 441-490) antibodyKCNN1 适用: 人, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 1 (KCNN1) (AA 1-90) antibodyKCNN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 1 (KCNN1) (C-Term) antibodyKCNN1 适用: 人, 大鼠, 豚鼠, Cow, 犬, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IP|IHC|ICC|Electrophysiology
Negative Control: (ABIN7236345)
Blocking Peptide: (ABIN7236345)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- KCNN1 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 1 (KCNN1))
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别名
- KCNN1
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背景
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SKCa1, Small conductance calcium-activated potassium channel protein 1,KCa2.1 is a member of the Ca2+-activated K+ channel family with small conductance that includes KCa2.2 (SK2) and KCa2.3 (SK3). The channel is voltage insensitive and is activated by intracellular Ca2+ in the submicromolar range. It has a similar topology to that of voltage-dependent K+ channels (KV channels), that is, six transmembrane domains and intracellular N- and C-termini. KCa2.1 channel expression is roughly confined to neuronal tissue, although there are some indications that it may be present in non-neuronal tissues as well. The sensitivity of KCa2.1 to the bee venom toxin Apamin (#STA-200) is a matter of some controversy. Expression of the human KCa2.1 in mammalian cell lines showed that most cells produce channels that can be blocked by Apamin. However, expression of KCa2.1 in Xenopus oocytes produced channels that were mostly insensitive to Apamin. Interestingly, the rat KCa2.1 is unable to form functional channels when expressed alone in either cell lines or oocytes.
Alternative names: KCNN1 (KCa2.1, SK1), SKCa1, Small conductance calcium-activated potassium channel protein 1 -
基因ID
- 54261
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NCBI登录号
- NM_002248
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UniProt
- P70606
抗原
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