KCNK9 抗体 (Extracellular)
Quick Overview for KCNK9 抗体 (Extracellular) (ABIN7043456)
抗原
See all KCNK9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 57-73, Extracellular
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原理
- A Rabbit Polyclonal Antibody to KCNK9 Channel
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特异性
- Extracellular, near the P1 loop
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交叉反应
- 人, 大鼠
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预测反应
- Human - 15,17 amino acid residues identical
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产品特性
- Anti-KCNK9 (extracellular) Antibody (ABIN7043456, ABIN7044953 and ABIN7044954) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the channel in living cells. It has been designed to recognize from rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DDYQQLELVILQSEPHR, corresponding to amino acid residues 57-73 of rat KCNK9
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亚型
- IgG
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anti-Potassium Channel, Subfamily K, Member 9 (KCNK9) (N-Term) antibody
KCNK9 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel, Subfamily K, Member 9 (KCNK9) antibodyKCNK9 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel, Subfamily K, Member 9 (KCNK9) (AA 36-85) antibodyKCNK9 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel, Subfamily K, Member 9 (KCNK9) (N-Term) antibodyKCNK9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel, Subfamily K, Member 9 (KCNK9) (AA 250-362) antibodyKCNK9 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel, Subfamily K, Member 9 (KCNK9) (AA 265-374) antibodyKCNK9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel, Subfamily K, Member 9 (KCNK9) (AA 1-100) antibodyKCNK9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: ICC
Negative Control: (ABIN7236330)
Blocking Peptide: (ABIN7236330)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- KCNK9 (Potassium Channel, Subfamily K, Member 9 (KCNK9))
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别名
- KCNK9
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背景
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Potassium channel subfamily K member 9, K2P9.1, TWIK-related acid-sensitive K+ channel 3, Two pore K+ channel KT3.2,KCNK9 (also named TASK3 or K2P9.1) is a member of the 2-pore (2P) domain K+ channels family that probably assemble as dimers to constitute a functional channel.1 These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The channels are regulated by diverse physical and chemical stimuli including temperature, pH , mechanical stretch, inhalation anesthetics, etc.2 The physiological role of the K2P channels is not yet clear, though they were proposed to participate in breathing, aldosterone secretion and anesthetic-mediated neuronal activity.In human, expression of KCNK9 is restricted in brain and its expression overlaps with the structurally related KCNK3 (TASK1, K2P3.1) channel. In rat, it is more widely expressed in other tissues as well as in brain. Unexpectedly, KCNK9 was found to be over-expressed between 5 to 100-fold in 44 % of breast cancer tumors tested. Transfection and over-expression of KCNK9 in cell lines promotes tumor growth and confers resistance to hypoxia and serum deprivation.3 Recently, KCNK9 was found to play an important role in K+-dependent apoptosis of cerebellar granules.4
Alternative names: KCNK9 (TASK-3), Potassium channel subfamily K member 9, K2P9.1, TWIK-related acid-sensitive K+ channel 3, Two pore K+ channel KT3.2 -
基因ID
- 84429
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NCBI登录号
- NM_016601
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UniProt
- Q9ES08
抗原
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