KCNK5 抗体 (Intracellular)
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Quick Overview for KCNK5 抗体 (Intracellular) (ABIN7043455)
抗原
See all KCNK5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 483-499, Intracellular
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原理
- A Rabbit Polyclonal Antibody to KCNK5 Channel
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - 14,17 amino acid residues identical
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产品特性
- Anti-KCNK5 Antibody is directed against an epitope of human KCNK5. Anti-KCNK5 Antibody (ABIN7043455 and ABIN7044945) can be used in western blot and immunohistochemistry applications. It has been designed to recognize KCNK5 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)YEQLMNEYNKANSPKGT, amino acid residues 483-499 of human KCNK5
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亚型
- IgG
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anti-Potassium Channel, Subfamily K, Member 5 (KCNK5) (AA 421-470) antibody
KCNK5 适用: 人, Cow, 马, 豚鼠, Bat, 猴 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel, Subfamily K, Member 5 (KCNK5) (AA 1-499) antibodyKCNK5 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2B4 unconjugated
anti-Potassium Channel, Subfamily K, Member 5 (KCNK5) (AA 236-285) antibodyKCNK5 适用: 人, 小鼠, 大鼠, Cow, 兔, Pig, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel, Subfamily K, Member 5 (KCNK5) (C-Term) antibodyKCNK5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:50
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: ICC
Negative Control: (ABIN7236326)
Blocking Peptide: (ABIN7236326)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- KCNK5 (Potassium Channel, Subfamily K, Member 5 (KCNK5))
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别名
- KCNK5
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背景
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Potassium channel subfamily K member 5, K2P5.1, TWIK-related acid sensitive K+ channel 2,KCNK5 (also named TWIK-related acid sensitive K+ channel 2, TASK-2 or K2P5.1) is a member of the 2-pore (2P) domain K+ channels family that includes at least 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C- termini. The functional channel is believed to be a dimer.K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH , mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators.As indicated by its name, KCNK5 (K2P5.1) is sensitive to variations in external pH . KCNK5 current is maximal at pH 8.8 but it is only 10 % at pH 6.5. The channel is expressed in several epithelial tissues including pancreas, lung, small intestine and specially kidney. In the kidney KCNK5 has an important function in NaHCO3 absorption in the proximal tubule as knockout mice for KCNK5 display metabolic acidosis and hypotension.
Alternative names: KCNK5 (TASK-2), Potassium channel subfamily K member 5, K2P5.1, TWIK-related acid sensitive K+ channel 2 -
基因ID
- 8645
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NCBI登录号
- NM_003740
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UniProt
- O95279
抗原
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