KCNK13 抗体 (1st Extracellular Loop)
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Quick Overview for KCNK13 抗体 (1st Extracellular Loop) (ABIN7043444)
抗原
See all KCNK13 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 1st Extracellular Loop, AA 54-69
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原理
- A Rabbit Polyclonal Antibody to KCNK13 Channel
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 15,16 amino acid residues identical
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产品特性
- Anti-KCNK13 (extracellular) Antibody is directed against an epitope in the 1st extracellular loop of the rat KCNK13 channel. Anti-KCNK13 (extracellular) Antibody (ABIN7043444, ABIN7045019 and ABIN7045020) can be used in western blot and immunohistochemical applications, and recognizes KCNK13 channel from mouse and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EERLANFSRGHNLSRE, corresponding to amino acid residues 54-69 of rat KCNK13
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亚型
- IgG
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anti-Potassium Channel Subfamily K Member 13 (KCNK13) (AA 292-408) antibody
KCNK13 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (C-Term) antibodyKCNK13 适用: 人, 大鼠, 马, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (C-Term) antibodyKCNK13 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (C-Term) antibodyKCNK13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (C-Term) antibodyKCNK13 适用: 人, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (Middle Region) antibodyKCNK13 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:50-1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236288)
Blocking Peptide: (ABIN7236288)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- KCNK13 (Potassium Channel Subfamily K Member 13 (KCNK13))
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别名
- KCNK13
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背景
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Synonyms: Potassium channel subfamily K member 13, Tandem pore domain halothane-inhibited K+ channel 1, K2P13.1
Description: KCNK13 (also named Tandem pore domain halotane inhibited K+ channel, THIK -1 or K2P13.1) is a member of the 2-pore (2P) domain K+ channels family that currently includes 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.1The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C- termini. It has been proposed that the functional channel unit is a dimer.K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH , mechanical stretch, inhalation anesthetics, etc. but are insensitive to classical K+ channel blockers.The KCNK13 channel is activated by arachidonic acid and inhibited by the volatile anesthetic halothane. The channel is relatively widely expressed in peripheral tissues such as kidney, heart, lung and liver but it is also expressed in brain.The physiological function of the KCNK13 channel is not clear but an involvement in the physiological response to reduced oxygen levels (hypoxia) has been proposed.2
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基因ID
- 64120
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NCBI登录号
- NM_022054
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UniProt
- Q9ERS0
抗原
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