KCNK13 抗体 (Extracellular)
Quick Overview for KCNK13 抗体 (Extracellular) (ABIN7043444)
抗原
See all KCNK13 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 54-69, Extracellular
-
原理
- A Rabbit Polyclonal Antibody to KCNK13 Channel
-
特异性
- 1st extracellular loop
-
交叉反应
- 小鼠, 大鼠
-
预测反应
- Mouse - identical, human - 15,16 amino acid residues identical
-
产品特性
- Anti-KCNK13 (extracellular) Antibody is directed against an epitope in the 1st extracellular loop of the rat KCNK13 channel. Anti-KCNK13 (extracellular) Antibody (ABIN7043444, ABIN7045019 and ABIN7045020) can be used in western blot and immunohistochemical applications, and recognizes KCNK13 channel from mouse and rat samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)EERLANFSRGHNLSRE, corresponding to amino acid residues 54-69 of rat KCNK13
-
亚型
- IgG
-
-
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (AA 292-408) antibody
KCNK13 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (C-Term) antibodyKCNK13 适用: 人, 大鼠, 马, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (C-Term) antibodyKCNK13 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (C-Term) antibodyKCNK13 适用: 人, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (C-Term) antibodyKCNK13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 13 (KCNK13) (Middle Region) antibodyKCNK13 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:50-1:200
Application Dilutions Western blot wb: 1:200
-
说明
-
Negative Control: (ABIN7236288)
Blocking Peptide: (ABIN7236288)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW).
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- KCNK13 (Potassium Channel Subfamily K Member 13 (KCNK13))
-
别名
- KCNK13
-
背景
-
Potassium channel subfamily K member 13, Tandem pore domain halothane-inhibited K+ channel 1, K2P13.1,KCNK13 (also named Tandem pore domain halotane inhibited K+ channel, THIK -1 or K2P13.1) is a member of the 2-pore (2P) domain K+ channels family that currently includes 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.1The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C- termini. It has been proposed that the functional channel unit is a dimer.K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH , mechanical stretch, inhalation anesthetics, etc. but are insensitive to classical K+ channel blockers.The KCNK13 channel is activated by arachidonic acid and inhibited by the volatile anesthetic halothane. The channel is relatively widely expressed in peripheral tissues such as kidney, heart, lung and liver but it is also expressed in brain.The physiological function of the KCNK13 channel is not clear but an involvement in the physiological response to reduced oxygen levels (hypoxia) has been proposed.2
Alternative names: KCNK13 (THIK-1), Potassium channel subfamily K member 13, Tandem pore domain halothane-inhibited K+ channel 1, K2P13.1 -
基因ID
- 64120
-
NCBI登录号
- NM_022054
-
UniProt
- Q9ERS0
抗原
-
