Plexin A3 抗体 (Extracellular, N-Term)
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Quick Overview for Plexin A3 抗体 (Extracellular, N-Term) (ABIN7043438)
抗原
See all Plexin A3 (PLXNA3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 440-453, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Plexin-A3
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat - identical, human - 12,14 amino acid residues identical
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产品特性
- Anti-Plexin-A3 (extracellular) Antibody (ABIN7043438, ABIN7045134 and ABIN7045135) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and indirect live cell flow cytometry. The antibody recognizes an extracellular epitope, and can potentially be used for detecting the protein in living cells. It has been designed to recognize PLXNA3 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KVRVDGSQDAQLYE, corresponding to amino acid residues 440-453 of mouse PLXNA3
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亚型
- IgG
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anti-Plexin A3 (PLXNA3) (AA 1050-1100) antibody
PLXNA3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IHC
Negative Control: (ABIN7236268)
Blocking Peptide: (ABIN7236268)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Plexin A3 (PLXNA3)
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别名
- PLXNA3
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背景
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Synonyms: PLXNA3, PLXN3, Semaphorin receptor SEX
Description: Plexins are type 1 transmembrane (TM) receptors acting as key regulatory proteins in a wide variety of developmental, regenerative and pathological processes. They are involved in guidance and motility of vascular, lymphatic vessel, and neuron growth, and in cancer metastasis.Plexin family includes 9 proteins: Plexin-A1-4, -B1-3, -C1 and -D1. Class A Plexins interact with the secreted class 3 Semaphorins, and require Neuropilins (nrps) as co-receptors.Plexin protein signaling results in cytosolic GTPase-activating protein activity including direct interactions with Rho GTPases and transient/catalytic interactions with Ras GTPases1,2.Plexin structure consists of an extracellular semaphorin domain, three Plexin-Semaphorin-Integrin (PSI) domains, and three immunoglobulin, Plexin, and transcription factor (IPT) domains. In addition, a single-spanning transmembrane domain, and a cytosolic region (CYTO) homologous with Ras GTPase-activating proteins (GAPs)2. The transmembrane region of Plexin-A3 is characterized by poly-glycine usually used for close helix-helix packing and aromatic residues that distort helix conformation and association. Plexin-A family members only have 22 residues spanning the membrane1.Mutations in Plexins have been reported in melanoma, lung, breast, pancreatic, and prostate cancers, strongly suggesting that their signaling may play a role in cancer development. Plexins are widely expressed in the nervous system and in the developing cerebral cortex2.
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基因ID
- 18846
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NCBI登录号
- NM_017514
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UniProt
- P70208
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途径
- Regulation of Cell Size
抗原
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