Periaxin 抗体 (Intracellular, N-Term)
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Quick Overview for Periaxin 抗体 (Intracellular, N-Term) (ABIN7043432)
抗原
See all Periaxin (PRX) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 155-170, Intracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Periaxin
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交叉反应
- 人, 小鼠, 大鼠
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交叉反应 （详细）
- Specific to isoform 1 also known as L-Periaxin (will not recognize isoform 2 known as S-Periaxin).
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预测反应
- Mouse,human - identical
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产品特性
- Anti-Periaxin Antibody (ABIN7043432, ABIN7044712 and ABIN7044713) is a highly specific antibody directed against an epitope of rat PRX. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize PRX from mouse, rat and human samples. The antibody specifically recognizes L-Periaxin. It does not recognize S-Periaxin.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DVEFSFPKFSRLRR, corresponding to amino acid residues 155-170 of rat PRX
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亚型
- IgG
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anti-Periaxin (PRX) (AA 1250-1350) antibody
PRX 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Periaxin (PRX) (Internal Region) antibodyPRX 适用: 小鼠, 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Periaxin (PRX) (AA 155-170), (Intracellular), (N-Term) antibodyPRX 适用: 大鼠 WB, IHC 宿主: 豚鼠 Polyclonal unconjugated
anti-Periaxin (PRX) (AA 1-91) antibodyPRX 适用: 小鼠, 人, 大鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:600
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:600
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236245)
Blocking Peptide: (ABIN7236245)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Periaxin (PRX)
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别名
- PRX
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背景
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Synonyms: PRX, CMT4F
Description: Periaxin protein is a membrane-associated protein expressed in myelinating Schwann cells. It is required for the stable maintenance and development of a normal myelin sheath in the peripheral nervous system. It is also a member of cytoskeletal complexes in lens fibers where it plays an important role in maturation, packing, and membrane organization of lens fiber cell1,2. The periaxin gene (PRX) encodes two protein isoforms, L-periaxin and S-periaxin generated by alternative mRNA splicing. These proteins contain N-terminal PDZ domains (PSD-95/Discs-large/ZO-1) important for organizing protein-protein interactions.L-periaxin is a component of the dystroglycan-dystrophin-related protein-2 complex (DRP2) linking the Schwann cell cytoskeleton to the extracellular matrix. Its location changes during myelination, at first the protein is localized to the adaxonal plasma membrane and later, in the abaxonal plasma membrane. S-periaxin is distributed in a uniform manner in the cytoplasm and the nucleus of the Schwann cell1-3. Mutations in the Periaxin gene are known to cause autosomal recessive demyelinating in Type 4F Charcot-Marie-Tooth (CMT4F) and Dejerine-Sottas disease3.Periaxin knockout mice develop normally myelinated peripheral nervous system at first but develop a late onset demyelinating peripheral neuropathy1.
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基因ID
- 78960
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NCBI登录号
- NM_020956
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UniProt
- Q63425
抗原
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