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- 抗原 See all Periaxin (PRX) 抗体
- Periaxin (PRX)
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抗原表位
- AA 155-170, Intracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Periaxin antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 原理
- A Rabbit Polyclonal Antibody to Periaxin
- 特异性
- Intracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 交叉反应 （详细）
- Specific to isoform 1 also known as L-Periaxin (will not recognize isoform 2 known as S-Periaxin).
- 预测反应
- Mouse,human - identical
- 产品特性
- Anti-Periaxin Antibody (ABIN7043432, ABIN7044712 and ABIN7044713) is a highly specific antibody directed against an epitope of rat PRX. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize PRX from mouse, rat and human samples. The antibody specifically recognizes L-Periaxin. It does not recognize S-Periaxin.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DVEFSFPKFSRLRR, corresponding to amino acid residues 155-170 of rat PRX
- 亚型
- IgG
- Top Product
- Discover our top product PRX Primary Antibody
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anti-Periaxin (PRX) (AA 1250-1350) antibody
PRX 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Periaxin (PRX) (Internal Region) antibodyPRX 适用: 小鼠, 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Periaxin (PRX) antibodyPRX 适用: 小鼠, 人, 大鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:600
Application Dilutions Western blot wb: 1:600
- 说明
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Negative Control: (ABIN7236245)
Blocking Peptide: (ABIN7236245)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Periaxin (PRX)
- 别名
- PRX (PRX 产品)
- 背景
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PRX, CMT4F,Periaxin protein is a membrane-associated protein expressed in myelinating Schwann cells. It is required for the stable maintenance and development of a normal myelin sheath in the peripheral nervous system. It is also a member of cytoskeletal complexes in lens fibers where it plays an important role in maturation, packing, and membrane organization of lens fiber cell1,2. The periaxin gene (PRX) encodes two protein isoforms, L-periaxin and S-periaxin generated by alternative mRNA splicing. These proteins contain N-terminal PDZ domains (PSD-95/Discs-large/ZO-1) important for organizing protein-protein interactions.L-periaxin is a component of the dystroglycan-dystrophin-related protein-2 complex (DRP2) linking the Schwann cell cytoskeleton to the extracellular matrix. Its location changes during myelination, at first the protein is localized to the adaxonal plasma membrane and later, in the abaxonal plasma membrane. S-periaxin is distributed in a uniform manner in the cytoplasm and the nucleus of the Schwann cell1-3. Mutations in the Periaxin gene are known to cause autosomal recessive demyelinating in Type 4F Charcot-Marie-Tooth (CMT4F) and Dejerine-Sottas disease3.Periaxin knockout mice develop normally myelinated peripheral nervous system at first but develop a late onset demyelinating peripheral neuropathy1.
Alternative names: Periaxin, PRX, CMT4F - 基因ID
- 78960
- NCBI登录号
- NM_020956
- UniProt
- Q63425
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