PTH2R 抗体 (Extracellular)
Quick Overview for PTH2R 抗体 (Extracellular) (ABIN7043430)
抗原
See all PTH2R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 125-137, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Parathyroid Hormone 2 Receptor
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特异性
- Extracellular, N-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 11,13 amino acid residues identical
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产品特性
- Anti-PTH2R (extracellular) Antibody (ABIN7043430, ABIN7045114 and ABIN7045115) is a highly specific antibody directed against an extracellular epitope of the rat Parathyroid hormone 2 receptor. The antibody can be used in western blot analysis. It has been designed to recognize PTH2 receptor from human, rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CFLQPDINIGKQE, corresponding to amino acid residues 125-137 of rat PTH2R
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亚型
- IgG
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anti-Parathyroid Hormone 2 Receptor (PTH2R) (AA 27-145) antibody
PTH2R 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Parathyroid Hormone 2 Receptor (PTH2R) (AA 27-143) antibodyPTH2R 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Parathyroid Hormone 2 Receptor (PTH2R) (N-Term) antibodyPTH2R 适用: 人, Cow, 猴 IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Parathyroid Hormone 2 Receptor (PTH2R) (Extracellular Domain) antibodyPTH2R 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Parathyroid Hormone 2 Receptor (PTH2R) (AA 27-145) antibodyPTH2R 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Parathyroid Hormone 2 Receptor (PTH2R) (AA 27-145) antibodyPTH2R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:600
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说明
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Negative Control: (ABIN7236237)
Blocking Peptide: (ABIN7236237)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- PTH2R (Parathyroid Hormone 2 Receptor (PTH2R))
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别名
- PTH2R
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背景
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Parathyroid hormone 2 receptor, PTH2 receptor, PTHR2,PTH (parathyroid hormone) regulates Ca2+ and phosphate homeostasis through its action on specific receptors in kidney and bone. There are two known PTH receptors in humans, PTH receptor type 1 (PTH1 receptor) and PTH receptor type 2 (PTH2 receptor)1.The PTH2 receptor is a member of a class B subfamily of G-protein-coupled receptors that includes the receptors for the glucagon-GHRH-VIP family of peptides (glucagon, GLP-I, GIP, GHRH, VIP, secretin, PACAP) and for calcitonin and CRF2. PTH2 receptor shares the same basic structure of the GPCR superfamily of proteins. A defining feature of the family B receptors is the relatively long extracellular N-terminal domain, which comprises about 150 amino acids and is important for ligand binding. The seven transmembrane domains are believed to be arranged in a circular or oval configuration, as seen in rhodopsin. The transmembrane domains are connected by three extracellular and three intracellular loops, and a C-terminal tail of about 130 amino acids extends intracellularly3.Northern blots of human messenger RNA (mRNA) show that the PTH2 receptor is most highly expressed in the central nervous system, preferentially in the hypothalamic regions and is also detected in the pancreas, testis, placenta, and lung4.Recent data support that PTH2 receptor is involved in hypothalamic releasing-factor secretion and pain5.
Alternative names: PTH2R, Parathyroid hormone 2 receptor, PTH2 receptor, PTHR2 -
基因ID
- 81753
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NCBI登录号
- NM_005048
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UniProt
- P70555
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途径
- cAMP Metabolic Process
抗原
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