Pannexin 3 抗体 (Intracellular)
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Quick Overview for Pannexin 3 抗体 (Intracellular) (ABIN7043428)
抗原
See all Pannexin 3 (PANX3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 156-170, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Pannexin 3
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交叉反应
- 小鼠, 大鼠
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预测反应
- Rat - identical, mouse - 13,15 amino acid residues
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产品特性
- Anti-Pannexin 3 Antibody is directed against an epitope of human Pannexin 3. Anti-Pannexin 3 Antibody (ABIN7043428, ABIN7044098 and ABIN7044099) can be used in western blot analysis. It was designed to recognize PANX3 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RLVQHMLKIRQKSSD, corresponding to amino acid residues 156-170 of human PANX3
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亚型
- IgG
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anti-Pannexin 3 (PANX3) (AA 135-215) antibody
PANX3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Pannexin 3 (PANX3) (Internal Region) antibodyPANX3 适用: 人 WB, ELISA, IF, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pannexin 3 (PANX3) (AA 143-192) antibodyPANX3 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Pannexin 3 (PANX3) (Middle Region) antibodyPANX3 适用: 哺乳动物 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236229)
Blocking Peptide: (ABIN7236229)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Pannexin 3 (PANX3)
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别名
- PANX3
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背景
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Synonyms: PANX3, PX3
Description: Pannexins are a class of membrane channels similar to the invertebrate Connexin family of gap channel proteins. There are currently three known types of pannexin channels and the exact role of these channels is yet to be fully discerned1.A recent study suggests that despite similarity to the connexin family these channels are not gap-junctions or "hemichannels" as described in some publications but fully operational channels. These conclusions were derived because pannexins, unlike gap-junctions, are found to be expressed and functional in single membranes facing the extracellular space and not as intercellular membranes in appositional cells.Pannexins are comprised of four transmembrane segments, two extracellular loops and both the amino and carboxy termini are facing the cytosol. Pannexins also have four conserved extracellular loop cysteines resulting in the possibility of two intra-pannexin disulfide bonds. Pannexin 3 has a glycosylation site at N254 and N71. Pannexin membrane channels are formed by 6-8 monomers and while pannexins 3's exact oligomeric number has not been determined yet it is expected to be 6 with a greater similarity to Pannexin 1 than 22.There are two known subtypes of Panx3 in mice with different molecular weight and distribution. The first, weighing 43 kDa is mostly expressed in cartilage skin tissues and also in low levels in heart ventricle tissue. The second, weighing 70 kDa, and possibly functioning as a dimer is detected in lung, liver, thymus and spleen tissues3.Since full understanding of pannexin 3 structure, expression and role in physiological and pathological tissues is yet to be obtained there is a definite need for further research.
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基因ID
- 116337
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NCBI登录号
- NM_052959
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UniProt
- Q96QZ0
抗原
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