P2RY2 抗体 (Extracellular)
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Quick Overview for P2RY2 抗体 (Extracellular) (ABIN7043424)
抗原
See all P2RY2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-24, Extracellular
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原理
- A Rabbit Polyclonal Antibody to P2Y2 Receptor
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特异性
- Extracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat, human - 13,mouse - 14,15 amino acid residues identical
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产品特性
- Anti-P2Y2 Receptor (extracellular) Antibody (ABIN7043424, ABIN7045138 and ABIN7045139) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect live cell flow cytometry, live cell imaging, and immunohistochemistry applications. It has been designed to recognize P2RY2 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (CD)TINGTWEGDELGYK, corresponding to amino acid residues 11- 24 of rat P2RY2
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亚型
- IgG
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anti-Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) antibody
P2RY2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4F11E7 unconjugated
anti-Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) (AA 21-120) antibodyP2RY2 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) antibodyP2RY2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) (AA 278-377) antibodyP2RY2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) (C-Term) antibodyP2RY2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) (AA 1-377) antibodyP2RY2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) (C-Term) antibodyP2RY2 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) (AA 227-244) antibodyKO Validated P2RY2 适用: 大鼠 WB, IHC, IF, IP, FACS, IC 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) (AA 11-24), (Extracellular) antibody (FITC)P2RY2 适用: 大鼠 FACS, LCI 宿主: 兔 Polyclonal FITC
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: ICC
Negative Control: (ABIN7236218)
Blocking Peptide: (ABIN7236218)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- P2RY2 (Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2))
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别名
- P2RY2
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背景
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P2Y purinoceptor 2, P2RY2, P2U1,P2Y receptors belong to the G-protein coupled receptor superfamily. P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiological responses, among them, cardiac function, platelet aggregation and SMC proliferation1.The mammalian P2Y family currently includes eight functional receptors, P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y142-4.The P2Y2 receptor is abundantly expressed in the apical membranes of several epithelial tissues including airway5. It has become a leading target for the treatment of cystic fibrosis. Activation of P2RY2 increases Cl- efflux and mucociliary clearance, effects that might relieve symptoms of cystic fibrosis. P2Y2 agonist therapy is tested in an attempt to bypass the dysfunctioning CFTR channel. Several P2Y2 receptor agonists, especially INS37217, being evaluated as possible targets for the treatment of cystic fibrosis.6
Alternative names: P2Y2 Receptor, P2Y purinoceptor 2, P2RY2, P2U1 -
基因ID
- 29597
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NCBI登录号
- NM_176072
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UniProt
- P41232
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途径
- Cellular Response to Molecule of Bacterial Origin, Smooth Muscle Cell Migration
抗原
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