P2RX3 抗体 (Intracellular)
Quick Overview for P2RX3 抗体 (Intracellular) (ABIN7043420)
抗原
See all P2RX3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 383-397, Intracellular
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原理
- A Rabbit Polyclonal Antibody to P2X3 Receptor
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,15 amino acid residues identical
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产品特性
- Anti-P2X3 Receptor Antibody (ABIN7043420, ABIN7045090 and ABIN7045091) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect flow cytometry, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize P2X3 receptor from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)VEKQSTDSGAYSIGH, corresponding to amino acid residues 383-397 of rat P2X3 receptor
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亚型
- IgG
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anti-Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) (Internal Region) antibody
P2RX3 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) (AA 241-340) antibodyP2RX3 适用: 人, 兔 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) (AA 44-317) antibodyP2RX3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) (AA 65-79), (Extracellular) antibodyKO Validated P2RX3 适用: 大鼠 WB, IHC, FACS, IF, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) antibodyP2RX3 适用: 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) (AA 328-397) antibodyP2RX3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) (C-Term), (Cytoplasmic Domain) antibodyP2RX3 适用: 人, 猴 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IP|IHC
Negative Control: (ABIN7236206)
Blocking Peptide: (ABIN7236206)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- P2RX3 (Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3))
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别名
- P2RX3
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背景
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P2RX3, P2X purinoceptor 3, ATP Receptor,The P2X3 receptor belongs to the ligand-gated ion channel P2X receptor family, that consists of seven receptor subtypes named P2X1-P2X7 and is activated by extracellular ATP.1,2,3All P2X subunits, with the exception of P2X6, can assemble to form homomeric or heteromeric functional channels.4-5 The different P2X receptors show distinct expression patterns. P2X1-6 has been found in the central and peripheral nervous system, while the P2X7 receptor is predominantly found in cells of the immune system. The P2X3 receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3 receptor to initiate nociceptive signals.6,7 Involvement of ATP in the mechanism of chronic pain has been also suggested.7,8 P2X3 receptor is now becoming a possible target for the development of pain therapeutics.
Alternative names: P2X3 Receptor, P2RX3, P2X purinoceptor 3 -
基因ID
- 81739
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NCBI登录号
- NM_002559
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UniProt
- P49654
抗原
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