OXGR1 抗体 (C-Term, Intracellular)
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Quick Overview for OXGR1 抗体 (C-Term, Intracellular) (ABIN7043418)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 319-332, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Oxoglutarate Receptor 1
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交叉反应
- 小鼠, 大鼠
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预测反应
- 14 amino acid residues identical,Rat - 12, human - 9
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产品特性
- Anti-OXGR1/GPR99 Antibody (ABIN7043418, ABIN7044895 and ABIN7044896) is a highly specific antibody directed against an epitope of the mouse Oxoglutarate receptor 1. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize OXGR1 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CKASGDLEQGKKDS, corresponding to amino acid residues 319-332 of mouse OXGR1
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亚型
- IgG
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anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) antibody
KD Validated OXGR1 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB4575 unconjugated Recombinant Antibody
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (Extracellular Domain) antibodyOXGR1 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) antibodyOXGR1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) antibodyKD Validated OXGR1 适用: 人, 小鼠, 大鼠 WB, IF, FACS, ICC 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (Internal Region) antibodyOXGR1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (AA 309-337), (C-Term) antibodyOXGR1 适用: 人 WB 宿主: 兔 Polyclonal RB40456 unconjugated
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (2nd Extracellular Domain) antibodyOXGR1 适用: 人 IHC (p), ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:600
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236198)
Blocking Peptide: (ABIN7236198)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- OXGR1 (Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1))
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别名
- OXGR1
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背景
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Synonyms: Oxoglutarate receptor 1, 2-Oxoglutarate receptor 1, Alpha-ketoglutarate receptor 1, aKGR, GPR80, P2RY15, P2Y15
Description: Oxoglutarate receptor 1 (OXGR1) is a receptor for α-ketoglutarate (αKG), a metabolite that is a citric acid cycle intermediate and a glutamine catabolism by-product1. αKG also serves as a metabolic marker and its interaction with OXGR1 has been shown to mediate the adaptive regulation of HCO3- secretion and NaCl reabsorption under acid-base stress3.OXGR1 belongs to the G-protein coupled receptor (GPCRs) protein family. Members of this group contain seven trans-membrane domains and respond to a large variety of ligands and thereby affect key cellular functions that are crucial for cell survival or proliferation2. OXGR1 belongs to a subset of metabolic GPCRs, along with receptors for succinate (GPR91), lactate (GPR81), fatty acids (FFAR) and many more3.OXGR1 is expressed in the kidney3,4 and in the heart, where it affects the contractile function, consistent with the finding that α-ketoglutarate levels are high in heart failure patients5.Because of its major role in maintaining cellular balance and its role in heart contractile activity, identification of molecules that can specifically activate or inhibit this receptor may be very useful in the development of novel therapeutic approach for pathological cardiac hypertrophy5.
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基因ID
- 239283
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NCBI登录号
- NM_080818
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UniProt
- Q6IYF8
抗原
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