OXGR1 抗体 (Intracellular)
Quick Overview for OXGR1 抗体 (Intracellular) (ABIN7043418)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 319-332, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Oxoglutarate Receptor 1
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特异性
- Intracellular, C-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- 14 amino acid residues identical,Rat - 12, human - 9
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产品特性
- Anti-OXGR1/GPR99 Antibody (ABIN7043418, ABIN7044895 and ABIN7044896) is a highly specific antibody directed against an epitope of the mouse Oxoglutarate receptor 1. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize OXGR1 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CKASGDLEQGKKDS, corresponding to amino acid residues 319-332 of mouse OXGR1
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亚型
- IgG
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anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (Extracellular Domain) antibody
OXGR1 适用: 人, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) antibodyKD Validated OXGR1 适用: 人, 小鼠, 大鼠 WB, IF, FACS, ICC 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (Internal Region) antibodyOXGR1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (AA 50-150) antibodyOXGR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (2nd Extracellular Domain) antibodyOXGR1 适用: 人 IHC (p), ELISA 宿主: 兔 Polyclonal unconjugated
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (AA 309-337), (C-Term) antibodyOXGR1 适用: 人 WB 宿主: 兔 Polyclonal RB40456 unconjugated
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (Extracellular Domain), (N-Term) antibodyOXGR1 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1) (3rd Extracellular Domain) antibodyOXGR1 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200-1:600
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说明
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Negative Control: (ABIN7236198)
Blocking Peptide: (ABIN7236198)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- OXGR1 (Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1))
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别名
- OXGR1
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背景
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Oxoglutarate receptor 1, 2-Oxoglutarate receptor 1, Alpha-ketoglutarate receptor 1, aKGR, GPR80, P2RY15, P2Y15,Oxoglutarate receptor 1 (OXGR1) is a receptor for α-ketoglutarate (αKG), a metabolite that is a citric acid cycle intermediate and a glutamine catabolism by-product1. αKG also serves as a metabolic marker and its interaction with OXGR1 has been shown to mediate the adaptive regulation of HCO3- secretion and NaCl reabsorption under acid-base stress3.OXGR1 belongs to the G-protein coupled receptor (GPCRs) protein family. Members of this group contain seven trans-membrane domains and respond to a large variety of ligands and thereby affect key cellular functions that are crucial for cell survival or proliferation2. OXGR1 belongs to a subset of metabolic GPCRs, along with receptors for succinate (GPR91), lactate (GPR81), fatty acids (FFAR) and many more3.OXGR1 is expressed in the kidney3,4 and in the heart, where it affects the contractile function, consistent with the finding that α-ketoglutarate levels are high in heart failure patients5.Because of its major role in maintaining cellular balance and its role in heart contractile activity, identification of molecules that can specifically activate or inhibit this receptor may be very useful in the development of novel therapeutic approach for pathological cardiac hypertrophy5.
Alternative names: Oxoglutarate receptor 1, 2-Oxoglutarate receptor 1, Alpha-ketoglutarate receptor 1, aKGR, GPR80, P2RY15, P2Y15, OXGR1, GPR99 -
基因ID
- 239283
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NCBI登录号
- NM_080818
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UniProt
- Q6IYF8
抗原
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