Otopetrin 1 抗体 (Intracellular Loop)
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Quick Overview for Otopetrin 1 抗体 (Intracellular Loop) (ABIN7043417)
抗原
See all Otopetrin 1 (OTOP1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 374-388, Intracellular Loop
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原理
- A Rabbit Polyclonal Antibody to Otopetrin-1 Channel
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,human - identical
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产品特性
- Anti-OTOP1 Antibody (ABIN7043417, ABIN7044503 and ABIN7044504) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize Otopetrin-1 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EKSLDESKNPARKLD, corresponding to amino acid residues 374 - 388 of mouse Otopetrin-1
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亚型
- IgG
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anti-Otopetrin 1 (OTOP1) (AA 415-504) antibody
OTOP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5E3 unconjugated
anti-Otopetrin 1 (OTOP1) (AA 360-388) antibodyOTOP1 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB29945 unconjugated
anti-Otopetrin 1 (OTOP1) (AA 414-544) antibodyOTOP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Otopetrin 1 (OTOP1) (AA 367-396), (Middle Region) antibodyOTOP1 适用: 小鼠, 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236195)
Blocking Peptide: (ABIN7236195)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Otopetrin 1 (OTOP1)
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别名
- OTOP1
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背景
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Synonyms: Proton Channel OTOP1, Otopetrin-1
Description: Otopetrin-1 (Otop-1) is a proton channel involved in sour taste recognition. It belongs to the Otopetrin proton channel family together with Otopetrins-2 and 31. Otop-1 is a dimeric structure, with each subunit forming 12 transmembrane helices divided into structurally similar N- and C-domains2.Taste recognition is very important because it enables to sample chemicals in the environment prior to digestion and hence, plays an important role in feeding and avoiding intoxication2. The sense of sour taste is caused by acids, and the first step in sour taste transduction is an influx of H+ ions through Otop-1 channel into the type three Taste Receptor Cells (TRCs). This leads to a decrease in intracellular pH and operation of a signaling cascade1-3.Otop-1 is specifically expressed in type three taste cells and exhibits the Zn2+ sensitivity that is a key feature observed in the proton current of sour taste cells4.Otop-1 also has a role in regulating intracellular Ca2+ levels required for the formation of otoconia in the vertebrate inner ear. Otoconia are complex calcium carbonate biominerals required for the sensation of gravity5.
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基因ID
- 21906
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NCBI登录号
- NM_177998
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UniProt
- Q80VM9
抗原
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