NTSR1 抗体 (2nd Extracellular Loop)
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Quick Overview for NTSR1 抗体 (2nd Extracellular Loop) (ABIN7886736)
抗原
See all NTSR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Extracellular Loop, AA 209-224
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原理
- A Rabbit Polyclonal Antibody to Neurotensin Receptor 1
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交叉反应
- 人, 大鼠
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预测反应
- rat - 12,16 amino acid residues identical,Mouse - 14
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产品特性
- Anti-Neurotensin Receptor 1 (extracellular) Antibody (ABIN7043383, ABIN7044767 and ABIN7044768) is a highly specific antibody directed against an epitope of the human NTSR1. The antibody can be used in western blot, immunohistochemistry, live cell imaging, and flow cytometry applications. It has been designed to recognize NTSR1 from human, mouse, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- EQNRSADGQHAGGLVC corresponding to amino acid residues 209-224 of human NTSR1
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亚型
- IgG
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anti-Neurotensin Receptor 1 (High Affinity) (NTSR1) (N-Term) antibody
NTSR1 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 1 (High Affinity) (NTSR1) (N-Term) antibodyNTSR1 适用: 人, 小鼠, 大鼠, 豚鼠, 马, Cow, 犬, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 1 (High Affinity) (NTSR1) (Center) antibodyNTSR1 适用: 人, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 1 (High Affinity) (NTSR1) (AA 188-290) antibodyNTSR1 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 1 (High Affinity) (NTSR1) (AA 181-230) antibodyNTSR1 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 1 (High Affinity) (NTSR1) (AA 1-67) antibodyNTSR1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 1 (High Affinity) (NTSR1) (AA 35-84) antibodyNTSR1 适用: 人, 小鼠, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 1 (High Affinity) (NTSR1) antibodyNTSR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 1 (High Affinity) (NTSR1) (AA 15-400) antibodyNTSR1 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 1 (High Affinity) (NTSR1) antibodyNTSR1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: 1:20
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236125)
Blocking Peptide: (ABIN7236125)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NTSR1 (Neurotensin Receptor 1 (High Affinity) (NTSR1))
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别名
- NTSR1
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背景
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Synonyms: NTR1, NTSR1, NTS1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH, NTRR
Description: Neurotensin receptor 1 (NTR1) is one of three receptors that mediate the effects of the tridecapeptide neurotensin. Neurotensin is synthesized and secreted from neurons in the central neural system (CNS) and from endocrine cells in the gastrointestinal tract.NTR1 and NTR2 belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily while the third neurotensin receptor NTR3 (also called Sortilin) is a type I membrane protein with a large extracellular domain. Both NTR1 and NTR3 bind neurotensin with high affinity while NTR2 binds it with low affinity.1NTR1 signals preferentially through Gaq, resulting in the activation phopholipase C and intracellular Ca2+ mobilization, although coupling with Gi/o and to Gs has been observed in some expression systems.NTR1 is mainly expressed in the brain and gastrointestinal tract. In the brain, NTR1 mediates body temperature regulation, feeding behavior and locomotion regulation. One of the best studied roles of NTR1 is the regulation of dopamine release suggesting that NTR1 can be a suitable target for the development of a new class of anti-psychotics.2 In the periphery, NTR1 expression has been linked to the control of intestine motility and in the stimulation of growth of the intestine mucosa in both physiological and pathological conditions. NTR1 has been shown to be upregulated in several human cancers where it stimulates tumor growth in response to locally produced neurotensin peptide.3
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基因ID
- 4923
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NCBI登录号
- NM_002531
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UniProt
- P30989
抗原
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