NPTN 抗体 (Extracellular)
-
- 抗原 See all NPTN 抗体
- NPTN (Neuroplastin (NPTN))
-
抗原表位
- AA 194-210, Extracellular
-
适用
- 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This NPTN antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Neuroplastin
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse,human - identical
- 产品特性
- Anti-Neuroplastin (extracellular) Antibody (ABIN7043382, ABIN7044710 and ABIN7044711)) is a highly specific antibody designed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting NPTN in living cells. It has been designed to recognize NPTN from rat, mouse and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)RKNASNMEYRINKPRAE, corresponding to amino acid residues 194-210 of rat NPTN
- 亚型
- IgG
- Top Product
- Discover our top product NPTN Primary Antibody
-
anti-Neuroplastin (NPTN) antibody
NPTN 适用: 人, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3C4 unconjugated
anti-Neuroplastin (NPTN) (Internal Region) antibodyNPTN 适用: 人, 大鼠, 小鼠, 犬, 兔, 猴, Cow, 豚鼠, 马, Pig, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (N-Term) antibodyNPTN 适用: 人, 兔, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (AA 29-200) antibodyNPTN 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (AA 201-250) antibodyNPTN 适用: 人, 大鼠, 小鼠, 犬, 兔, 猴, Cow, 豚鼠, 马, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (Middle Region) antibodyNPTN 适用: 人, 大鼠, 小鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (AA 51-150) antibodyNPTN 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) antibodyNPTN 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (AA 108-157) antibodyNPTN 适用: 人, 大鼠, 小鼠, 犬, 兔, 猴, Cow, 豚鼠, 马, Pig, 斑马鱼, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Neuroplastin (NPTN) (Middle Region) antibodyNPTN 适用: 人, 大鼠, 小鼠, 犬, 兔, Cow, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:120
Application Dilutions Western blot wb: 1:400
- 说明
-
Negative Control: BLP-NR090
Blocking Peptide: BLP-NR090
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
- 抗原
- NPTN (Neuroplastin (NPTN))
- 别名
- NPTN (NPTN 产品)
- 背景
-
NPTN, Glycoprotein 55/65, GP55, GP65, Np55, Np65, Stromal cell-derived receptor 1, SDR1, SDFR1,The neuroplastins Np55 and Np65 comprise a superfamily of neuronal and synapse enriched immunoglobulin molecules. They play an important role in a number of vital synaptic and neuronal activities including cell adhesion in the case of Np65. Np65 and Np55 are identical in structure except for the N-terminal Np65-specific Ig1 domain. They also play a key role in the localization of GABA(A) receptors in inhibitory synapses.Neuroplastins have two Ig domains that project into the extracellular space and are followed by a single 21 amino-acid membrane spanning sequence and a 34 amino-acid intracellular domain. The intracellular domain is mostly comprised of charged and neutral residues but also of a few hydrophobic residues. The N-terminus includes a 28 amino-acid signal peptide. In addition, neuroplastins contain a glutamate residue in their transmembrane domain which is important for molecular interactions within the membrane region.Although Np55 and Np65 are closely related in structure there are significant differences in terms of their expression. Np65 is tissue specific and is expressed mostly in forebrain neurons in the cortex, hippocampus and striatum. It has an anterior-posterior axis of expression. It is also expressed in lower amounts in the thalamus and hypothalamus. In contrast, Np55 is expressed throughout the brain in varying amounts.Currently, neuroplastins are not directly implicated in human diseases however several possible links have been discovered. A single nucleotide polymorphism (SNP) in the human neuroplastin locus is associated with reduced cortical thickness and impaired intellectual ability in adolescents. Furthermore, other SNPs in neuroplastin has been found to be either a risk or protecting factor for schizophrenia in animal models1.
Alternative names: Neuroplastin, NPTN, Glycoprotein 55/65, GP55, GP65, Np55, Np65, Stromal cell-derived receptor 1, SDR1, SDFR1 - 基因ID
- 56064
- NCBI登录号
- NM_012428
- UniProt
- P97546
- 途径
- Regulation of long-term Neuronal Synaptic Plasticity
-
