NRP2 抗体 (Extracellular)
Quick Overview for NRP2 抗体 (Extracellular) (ABIN7043380)
抗原
See all NRP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 747-758, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Neuropilin-2
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,mouse - 11,12 amino acid residues identical
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产品特性
- Anti-Neuropilin-2 (NRP2) (extracellular) Antibody (ABIN7043380, ABIN7044700 and ABIN7044701) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunohistochemistry, and indirect flow cytometry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the protein in living cells. It has been designed to recognize NRP2 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)REDQGGEWKHGR, corresponding to amino acid residues 747-758 of human neuropilin-2
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亚型
- IgG
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anti-Neuropilin 2 (NRP2) (AA 231-490) antibody
NRP2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 2 (NRP2) (AA 150-420) antibodyNRP2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 2 (NRP2) antibodyNRP2 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 2 (NRP2) (AA 60-209) antibodyNRP2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 2 (NRP2) (AA 621-715) antibodyNRP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B8 unconjugated
anti-Neuropilin 2 (NRP2) (N-Term) antibodyNRP2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 2 (NRP2) antibodyNRP2 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 2 (NRP2) (AA 621-715) antibodyNRP2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Neuropilin 2 (NRP2) antibodyNRP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 2 (NRP2) (AA 1-926) antibodyNRP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7236118)
Blocking Peptide: (ABIN7236118)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- NRP2 (Neuropilin 2 (NRP2))
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别名
- NRP2
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背景
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Vascular endothelial cell growth factor 165 receptor 2, VEGF165R2,The neuropilins (NRPs) are single-pass multifunctional transmembrane glycoproteins that play an important role in cell development, immunity and cancer, and physiological and pathological angiogenesis. They were first discovered as regulators of nervous system development, acting as semaphorin co-receptors with plexins, as well as enhancers of cellular responses to members of the vascular endothelial growth factor (VEGF) family.The NRP family comprises two members: Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2), which are usually expressed as homodimers but can also appear as heterodimers. NRP2 contains a large extracellular N-terminal which consists of five domains, a short transmembrane domain and a small cytoplasmic domain1-3. NRP2 is expressed in a wide variety of cells including endothelial cells, neurons, pancreatic islet cells, hepatocytes, melanocytes and osteoblasts. NRP2 has been shown to mediate proliferation, survival, and migration of tumor cells3.NRP2 knockout mice studies show that mice are viable without defects in blood vessels but display abnormal lymphatic development and defects of the central and peripheral nervous systems2.
Alternative names: Neuropilin-2 (NRP2), Vascular endothelial cell growth factor 165 receptor 2, VEGF165R2 -
基因ID
- 8828
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NCBI登录号
- NM_003872
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UniProt
- O60462
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途径
- Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
抗原
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