Neuropilin 1 抗体 (Extracellular, N-Term) (FITC)
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Quick Overview for Neuropilin 1 抗体 (Extracellular, N-Term) (FITC) (ABIN7043379)
抗原
See all Neuropilin 1 (NRP1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 502-514, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Neuropilin-1 (NRP1) (extracellular) conjugated to the fluorescent dye FITC.
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,mouse - identical
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产品特性
- Anti-Neuropilin-1 (NRP1) (extracellular) Antibody (ABIN7043378, ABIN7044702 and ABIN7044703) is a highly specific antibody directed against an extracellular epitope of the human protein. The antibody can be used in western blot, immunocytochemistry, and live cell flow cytometry applications. It has been designed to recognize NRP1 from human, mouse, and rat samples. \nAnti-Neuropilin-1 (NRP1)-FITC Antibody (ABIN7043378, ABIN7044702 and ABIN7044703)-F) is directly conjugated to fluorescein isothiocyanate (FITC) fluorophore. This conjugated antibody has been developed to be used in immunofluorescent applications such as direct flow cytometry and live cell imaging.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)GGKHRENKVFMRK, corresponding to amino acid residues 502-514 of human neuropilin-1
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亚型
- IgG
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anti-Neuropilin 1 (NRP1) (AA 646-814) antibody
NRP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 1 (NRP1) (AA 646-814) antibodyNRP1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Neuropilin 1 (NRP1) (AA 22-131) antibodyNRP1 适用: 人 WB, IP, ELISA 宿主: 小鼠 Monoclonal 1B3 unconjugated
anti-Neuropilin 1 (NRP1) (AA 21-250) antibodyNRP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 1 (NRP1) antibodyNRP1 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 1 (NRP1) (AA 722-750), (C-Term) antibodyNRP1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22995 unconjugated
anti-Neuropilin 1 (NRP1) (AA 722-750) antibodyNRP1 适用: 人 WB, IHC, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 1 (NRP1) (AA 45-59) antibodyNRP1 适用: 人 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 5B1E11 unconjugated
anti-Neuropilin 1 (NRP1) antibodyNRP1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB180 unconjugated Recombinant Antibody
anti-Neuropilin 1 (NRP1) (AA 504-827) antibodyNRP1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: The optimal concentration should be determined by the user
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7236114)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 15 μL or 50 μL double distilled water (DDW), depending on the sample size.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Neuropilin 1 (NRP1)
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别名
- NRP1
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背景
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Synonyms: Vascular endothelial cell growth factor 165 receptor, VEGF165R, CD304
Description: Neuropilins (NRPs) are co-receptors for class 3 semaphorins, polypeptides with key roles in axonal guidance, and for members of the VEGF (vascular endothelial growth factor) family of angiogenic cytokines.Neuropilin 1 (NRP1) is a transmembrane glycoprotein and comprises a large extracellular region containing multiple domains, a single transmembrane domain and a small cytoplasmic domain, also with a number of protein interacting domains.Class 3 semaphorins bind NRP1 (and NRP2) with different, and partially overlapping, specificities and affinities. Plexin A1 and Plexin A2 are the major signaling receptors for class 3 semaphorins, and complex with NRPs and semaphorins to form a holoreceptor essential for mediating effects of semaphorins on growth-cone collapse and axonal guidance in neurogenesis. The major VEGF-A signaling receptor, VEGF receptor 2, forms complexes with NRP1 and is important for optimal VEGFR2 signaling and function in endothelial cells.Targeted disruption of the NRP1 gene has demonstrated an essential dual role of these molecules in neurogenesis and cardiovascular development. NRP1-null mice die with a spectrum of cardiovascular and neuronal defects1.
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基因ID
- 8829
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NCBI登录号
- NM_001024628
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UniProt
- O14786
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途径
- Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals
抗原
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