NETO2 抗体 (Extracellular)
Quick Overview for NETO2 抗体 (Extracellular) (ABIN7043377)
抗原
See all NETO2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 189-202, Extracellular
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原理
- A Rabbit Polyclonal Antibody to NETO2
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-NETO2 (extracellular) Antibody (ABIN7043377, ABIN7044386 and ABIN7044387) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NETO2 from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RSSQVEQEEKTKPG, corresponding to amino acid residues 189-202 of rat NETO2
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亚型
- IgG
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anti-Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) (AA 378-525) antibody
NETO2 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) (AA 1-148) antibodyNETO2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) (AA 1-148) antibodyNETO2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) (AA 426-525) antibodyNETO2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3E3 unconjugated
anti-Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) (AA 174-203), (N-Term) antibodyNETO2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB33341 unconjugated
anti-Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) (C-Term) antibodyNETO2 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) (AA 36-85) antibodyNETO2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 马, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) (AA 180-229) antibodyNETO2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 小鸡, 猴, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) (N-Term) antibodyNETO2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 马, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7236110)
Blocking Peptide: (ABIN7236110)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- NETO2 (Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2))
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别名
- NETO2
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背景
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Neuropilin and tolloid-like protein 2, Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2, BTCL2,NETO proteins are auxiliary subunits that play a crucial role in the modulation of the biophysical properties of Kainate-type glutamate receptors (KARs). KARs are activated to modulate synaptic transmission, network excitability and synaptogenesis. NETO proteins modulate their activity both in vivo and in vitro mostly by regulating the surface expression and synaptic targeting of KARs in neurons.NETO protein expression has been characterized in the adult brain. NETO1 and NETO2 are highly homologous but have different expression patterns and distinct functional effects. High NETO2 expression levels can be found throughout the mammalian brain1,2.The NETO2 structure reveals a single-pass transmembrane protein that contains an extracellular region with two CUB domains that mediates interactions with KAR subunits. The C-terminus is important for modifying and regulating the synaptic abundance of KARs. The intracellular region of NETO2 can be phosphorylated by various kinases in vitro,which regulates synaptic targeting of KARs3.
Alternative names: NETO2, Neuropilin and tolloid-like protein 2, Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2, BTCL2 -
基因ID
- 307757
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NCBI登录号
- NM_018092
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UniProt
- C6K2K4
抗原
-
