NPY4R 抗体 (C-Term, Intracellular)
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Quick Overview for NPY4R 抗体 (C-Term, Intracellular) (ABIN7043374)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 326-340, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Neuropeptide Y4 Receptor
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,15 amino acid residues identical
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产品特性
- Anti-NPY4R Antibody is directed against an epitope of the rat neuropeptide Y4 receptor (NPY4R). Anti-NPY4R Antibody (ABIN7043374 and ABIN7044672) can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize NPY4R from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- NINFKKDIKALVLTC corresponding to amino acid residues 326-340 of rat NPY4R
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亚型
- IgG
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anti-Neuropeptide Y Receptor Y4 (NPY4R) (Cytoplasmic Domain) antibody
NPY4R 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y4 (NPY4R) (N-Term) antibodyNPY4R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y4 (NPY4R) (Extracellular Domain) antibodyNPY4R 适用: 人, 马, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y4 (NPY4R) (AA 1-375) antibodyNPY4R 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y4 (NPY4R) (AA 328-375) antibodyNPY4R 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y4 (NPY4R) (AA 1-80) antibodyNPY4R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y4 (NPY4R) antibodyNPY4R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y4 (NPY4R) (3rd Cytoplasmic Domain) antibodyNPY4R 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:100
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IHC
Negative Control: (ABIN7236098)
Blocking Peptide: (ABIN7236098)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NPY4R (Neuropeptide Y Receptor Y4 (NPY4R))
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别名
- NPY4R
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背景
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Synonyms: Neuropeptide Y4 receptor, Neuropeptide Y receptor type 4, Pancreatic polypeptide receptor 1, PPYR1
Description: Neuropeptide Y (NPY) is a 36 amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems.1 It belongs to the NPY family, along with peptide YY (PYY) and pancreatic polypeptide (PP). NPY is involved in the regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction.2NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R), and Y6 (NPY6R).2 Four of these (Y1, Y2, Y4, and Y5) are expressed in humans.2The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.3 Based on their high frequency and density in steroid hormone-producing tumors, the NPYRs might be of potential use in tumor management.2NPY4R preferentially binds PP, while NPY1R, NPY2R, and NPY5R bind both NPY and PP.NPY1R, NPY2R, and NPY5R share a low degree of identity (27-31 % overall). NPY4R is more similar to NPY1R, displaying an overall identity of 43-53 %.4Human NPY4R (also named pancreatic polypeptide receptor 1) mRNA is highly expressed in the small and large intestines and the prostate. Tissue distribution studies in human and mouse suggest potential roles for NPY4R in the gastrointestinal tract, heart, and prostate, as well as in neural and endocrine signaling. Only low levels of NPY4R expression in various areas of brain were displayed.5
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基因ID
- 29471
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NCBI登录号
- NM_005972
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UniProt
- Q63447
抗原
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