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NPY2R 抗体 (Intracellular)

NPY2R 适用: 小鼠 WB, IF, IHC, IC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7043373
发货至: 中国
  • 抗原 See all NPY2R 抗体
    NPY2R (Neuropeptide Y Receptor Y2 (NPY2R))
    抗原表位
    • 15
    • 13
    • 11
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 346-364, Intracellular
    适用
    • 55
    • 26
    • 20
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    小鼠
    宿主
    • 56
    • 3
    • 2
    克隆类型
    • 58
    • 3
    多克隆
    标记
    • 29
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NPY2R antibody is un-conjugated
    应用范围
    • 49
    • 27
    • 13
    • 13
    • 10
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunochromatography (IC)
    原理
    A Rabbit Polyclonal Antibody to Neuropeptide Y2 Receptor
    特异性
    Intracellular, C-terminus
    交叉反应
    小鼠, 大鼠
    预测反应
    Rat - identical, human - 18,19 amino acid residues identical
    产品特性
    Anti-NPY2R Antibody is directed against an epitope of the mouse neuropeptide Y2 receptor (NPY2R). Anti-NPY2R Antibody (ABIN7043373, ABIN7044670 and ABIN7044671) can be used in western blot analysis, immunohistochemistry, and immunocytochemical applications. It has been designed to recognize NPY2R from human, rat, and mouse samples.
    纯化方法
    Affinity purified on immobilized antigen.
    免疫原

    Immunogen: Synthetic peptide

    Immunogen Sequence: CEQRLDAIHSEVSMTFKAK, corresponding to amino acid residues 346-364 of mouse NPY2R

    亚型
    IgG
    Top Product
    Discover our top product NPY2R Primary Antibody
  • 应用备注

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

    Application Dilutions Western blot wb: 1:200

    说明

    Negative Control: (ABIN7236094)

    Blocking Peptide: (ABIN7236094)

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    0.2 mL double distilled water (DDW).
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4
    储存条件
    4 °C,-20 °C
    储存方法

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • 抗原
    NPY2R (Neuropeptide Y Receptor Y2 (NPY2R))
    别名
    NPY2R (NPY2R 产品)
    背景
    Neuropeptide Y2 receptor, Neuropeptide Y receptor type 2, NPY Y2 receptor,Neuropeptide Y (NPY) is a 36-amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems.1 It belongs to the NPY family, together with peptide YY (PYY) and pancreatic polypeptide (PP). NPY is involved in regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction.2NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R), and Y6 (NPY6R).2 Four of these, Y1, Y2, Y4, and Y5, are expressed in humans.2The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.3 Based on the high frequency and density of NPY receptors in steroid hormone-producing tumors, the NPY receptors might be of potential use in tumor management.2NPY2R is primarily expressed in neurons as a presynaptic receptor. It is also strongly expressed in epithelia of the visceral tissues, including colon and kidney.4 NPY2R is involved in inhibition of neurotransmitter release mediated by NPY.5 Release of glutamate, the principal neuroexcitatory transmitter, is inhibited via the NPY2R receptor.6 Involvement of NPY2R in feeding behavior was also reported. PYY(3-36), an NPY2R agonist, acts to inhibit feeding via NPY2R.7

    Alternative names: NPY2R, Neuropeptide Y2 receptor, Neuropeptide Y receptor type 2, NPY Y2 receptor
    基因ID
    18167
    NCBI登录号
    NM_000910
    UniProt
    P97295
    途径
    cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour
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