NPY2R 抗体 (Intracellular)
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- 抗原 See all NPY2R 抗体
- NPY2R (Neuropeptide Y Receptor Y2 (NPY2R))
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抗原表位
- AA 346-364, Intracellular
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NPY2R antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunochromatography (IC)
- 原理
- A Rabbit Polyclonal Antibody to Neuropeptide Y2 Receptor
- 特异性
- Intracellular, C-terminus
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Rat - identical, human - 18,19 amino acid residues identical
- 产品特性
- Anti-NPY2R Antibody is directed against an epitope of the mouse neuropeptide Y2 receptor (NPY2R). Anti-NPY2R Antibody (ABIN7043373, ABIN7044670 and ABIN7044671) can be used in western blot analysis, immunohistochemistry, and immunocytochemical applications. It has been designed to recognize NPY2R from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CEQRLDAIHSEVSMTFKAK, corresponding to amino acid residues 346-364 of mouse NPY2R
- 亚型
- IgG
- Top Product
- Discover our top product NPY2R Primary Antibody
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: (ABIN7236094)
Blocking Peptide: (ABIN7236094)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- NPY2R (Neuropeptide Y Receptor Y2 (NPY2R))
- 别名
- NPY2R (NPY2R 产品)
- 背景
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Neuropeptide Y2 receptor, Neuropeptide Y receptor type 2, NPY Y2 receptor,Neuropeptide Y (NPY) is a 36-amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems.1 It belongs to the NPY family, together with peptide YY (PYY) and pancreatic polypeptide (PP). NPY is involved in regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction.2NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R), and Y6 (NPY6R).2 Four of these, Y1, Y2, Y4, and Y5, are expressed in humans.2The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.3 Based on the high frequency and density of NPY receptors in steroid hormone-producing tumors, the NPY receptors might be of potential use in tumor management.2NPY2R is primarily expressed in neurons as a presynaptic receptor. It is also strongly expressed in epithelia of the visceral tissues, including colon and kidney.4 NPY2R is involved in inhibition of neurotransmitter release mediated by NPY.5 Release of glutamate, the principal neuroexcitatory transmitter, is inhibited via the NPY2R receptor.6 Involvement of NPY2R in feeding behavior was also reported. PYY(3-36), an NPY2R agonist, acts to inhibit feeding via NPY2R.7
Alternative names: NPY2R, Neuropeptide Y2 receptor, Neuropeptide Y receptor type 2, NPY Y2 receptor - 基因ID
- 18167
- NCBI登录号
- NM_000910
- UniProt
- P97295
- 途径
- cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour
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