NrCAM 抗体 (Extracellular)
Quick Overview for NrCAM 抗体 (Extracellular) (ABIN7043369)
抗原
See all NrCAM (NRCAM) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 583-597, Extracellular
-
原理
- A Rabbit Polyclonal Antibody to NrCAM
-
特异性
- Extracellular, N-terminus
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- human - 13,16 amino acid residues identical,Mouse - 15
-
产品特性
- Anti-NrCAM (extracellular) Antibody (ABIN7043369, ABIN7044690 and ABIN7044691) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize NrCAM from human, rat, and mouse samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)KDNGELPN DERFSVD, corresponding to amino acid residues 583-597 of rat NrCAM
-
亚型
- IgG
-
-
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 1192-1255) antibody
NRCAM 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7D8C5 unconjugated
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 1194-1299) antibodyNRCAM 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Atto 594)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Atto 594
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Atto 488)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Atto 488
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Atto 390)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Atto 390
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibodyNRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 unconjugated
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (HRP)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 HRP
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (FITC)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 FITC
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Biotin)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Biotin
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (PE)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 PE
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
-
说明
-
Negative Control: (ABIN7236074)
Blocking Peptide: (ABIN7236074)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))
-
别名
- NRCAM
-
背景
-
Neuronal cell adhesion molecule, Nr-CAM, NgCAM-related cell adhesion molecule, Ankyrin-binding cell adhesion molecule, Neuronal surface protein Bravo, HBravo,NrCAM (Neuron-glia related cell adhesion molecule) is a cell adhesion molecule that belongs to the immunoglobulin-class (Ig) of the L1 family. NrCAM promotes axon growth and repulsion through trans homophilic binding of extracellular domains and intracellular coupling of the conserved cytoplasmic domains to the actin cytoskeleton. This interaction occurs through ankyrin B and ezrin-radixin-moesin adaptors. In addition, NrCAM is responsible for controlling dendritic spine densities, axonal guidance and targeting, and neurite outgrowth by acting as a co-receptor molecule at the neuronal cell surface1,2.NrCAM is highly expressed in the cortex1,3. Its structure contains a PDZ binding motif with the potential to bind PSD scaffold proteins PSD-95 and SAP102. The Ig domains of the protein mediate homophilic and heterophilic binding to multiple ligands2,3.Genetic polymorphisms in the NrCAM gene are linked to autism spectrum disorders, intellectual disability and addictive behavior. NrCAM knockout mice demonstrate autism spectrum disorder related behaviors including impaired sociability, cognitive inflexibility, hypersensitivity to sensory stimuli and altered visual cortical responses.
Alternative names: NrCAM, Neuronal cell adhesion molecule, Nr-CAM, NgCAM-related cell adhesion molecule, Ankyrin-binding cell adhesion molecule, Neuronal surface protein Bravo, Hbravo -
基因ID
- 497815
-
NCBI登录号
- NM_001037132
-
UniProt
- P97686
-
途径
- Regulation of Cell Size
抗原
-
