NCS1 抗体 (Intracellular)
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北京 101111
Quick Overview for NCS1 抗体 (Intracellular) (ABIN7886265)
抗原
See all NCS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 40-53, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Neuronal Calcium Sensor 1
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-NCS1 Antibody is directed against an epitope of the rat Neuronal calcium sensor 1. Anti-NCS1 Antibody (ABIN7043367, ABIN7044204 and ABIN7044205) can be used in western blot analysis. It has been designed to recognize NCS1 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)SGQLDAAGFQKIYK, corresponding to amino acid residues 40-53 of rat NCS1
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亚型
- IgG
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anti-Neuronal Calcium Sensor 1 (NCS1) antibody
KD Validated NCS1 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 24GB25 unconjugated Recombinant Antibody
anti-Neuronal Calcium Sensor 1 (NCS1) antibodyNCS1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Calcium Sensor 1 (NCS1) (AA 1-190) antibodyNCS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-Neuronal Calcium Sensor 1 (NCS1) (AA 1-190) antibodyNCS1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Calcium Sensor 1 (NCS1) (AA 1-190) antibodyNCS1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Calcium Sensor 1 (NCS1) (N-Term) antibodyNCS1 适用: 人, 大鼠, 小鼠, 斑马鱼, Cow, 小鸡, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Calcium Sensor 1 (NCS1) (Middle Region) antibodyNCS1 适用: 人, 大鼠, 小鼠, 斑马鱼, Cow, 犬, 豚鼠, 马, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Calcium Sensor 1 (NCS1) (N-Term) antibodyNCS1 适用: 人, 大鼠, 小鼠, 斑马鱼, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Calcium Sensor 1 (NCS1) (AA 118-144) antibodyNCS1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Calcium Sensor 1 (NCS1) (C-Term) antibodyNCS1 适用: 人, 大鼠, 小鼠, 斑马鱼, Cow, 犬, 豚鼠, 马, 小鸡, 非洲爪蟾, Bat, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236071)
Blocking Peptide: (ABIN7236071)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NCS1 (Neuronal Calcium Sensor 1 (NCS1))
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别名
- NCS1
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背景
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Synonyms: Neuronal calcium sensor 1, Frequenin homolog, Frequenin-like protein, FREQ, FLUP
Description: Neuronal calcium sensor-1 (NCS-1) is a member of the neuronal calcium sensor family of EF-hand Ca2+-binding proteins that triggers different biological processes to regulate signal transduction in neurons and photoreceptor cells. This family of proteins includes 15 members and is primarily expressed in neurons. The protein interacts with the G-protein coupled receptor (GPCR) Dopamine D2 receptor (D2R), and the cognate kinases GRK1 and GRK2. NCS-1 responds to changes in intracellular Ca2+ concentration and is involved in many important physiological functions including the regulation of neurotransmitter release, synaptic plasticity, learning and memory, neurite growth, and neuronal survival1,2.NCS-1 structure is characterized by 4 helix-loop-helix motifs, called EF-hand motifs able to bind Ca2+ ions. These domains are separated by a short loop containing a conserved glycine residue. NCS-1 is targeted to the plasma membrane by an N-terminal myristoylation group through the action of N-miristoyltransferase. Opposite to the EF-motifs is a wide hydrophobic crevice (HC). This area has the ability to interact with various physiological targets2,3.NCS-1 dysfunctions are linked to mental conditions, such as bipolar disorder, schizophrenia and autism2.
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基因ID
- 65153
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NCBI登录号
- NM_014286
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UniProt
- P62168
抗原
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