NMBR 抗体 (3rd Intracellular Loop)
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Quick Overview for NMBR 抗体 (3rd Intracellular Loop) (ABIN7043364)
抗原
See all NMBR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 3rd Intracellular Loop, AA 241-256
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原理
- A Rabbit Polyclonal Antibody to Bombesin Receptor 1/Neuromedin B Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,dog - identical, rat - 15,16 amino acid residues identical
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产品特性
- Anti-Bombesin Receptor 1 (NMBR) Antibody is directed against a well conserved epitope located in the 3rd intracellular loop of the human BB1 receptor (neuromedin B receptor). Anti-Bombesin Receptor 1 (NMBR) Antibody (ABIN7043364 and ABIN7043939) can be used in western blot and immunocytochemical applications, and will recognize BB1R from human, rat, mouse, and dog samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KSAHNLPGEYNEHTKK, corresponding to amino acid residues 241-256 of human BB1R
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亚型
- IgG
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anti-Neuromedin B Receptor (NMBR) (Cytoplasmic Domain) antibody
NMBR 适用: 人, 小鼠, Bat, Cow, 马, Pig, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin B Receptor (NMBR) antibodyNMBR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin B Receptor (NMBR) (Internal Region) antibodyNMBR 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin B Receptor (NMBR) (AA 1-41) antibodyNMBR 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin B Receptor (NMBR) (N-Term) antibodyNMBR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin B Receptor (NMBR) (Internal Region) antibodyNMBR 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin B Receptor (NMBR) (Internal Region) antibodyNMBR 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin B Receptor (NMBR) (AA 1-30), (N-Term) antibodyNMBR 适用: 人 WB 宿主: 兔 Polyclonal RB36472 unconjugated
anti-Neuromedin B Receptor (NMBR) (AA 221-270) antibodyNMBR 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin B Receptor (NMBR) (3rd Cytoplasmic Domain) antibodyNMBR 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:1000
FC: The optimal concentration should be determined by the user
ICC: 1:1000
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236060)
Blocking Peptide: (ABIN7236060)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NMBR (Neuromedin B Receptor (NMBR))
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别名
- NMBR
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背景
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Synonyms: BB1R, Neuromedin B receptor, Neuromedin-B-preferring bombesin receptor
Description: Bombesin receptor 1 (BB1) is a member of a family of receptors that binds the 14 amino acid peptide bombesin. Bombesin was initially isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP) and neuromedin B (NMB), 27 and 10 amino acid homologues, respectively.1BB1 is the preferred receptor for NMB (therefore it is also known as NMB receptor) while BB2 is the preferred receptor for GRP.2 BB3 was the third member of the bombesin family of receptors to be cloned based upon its sequence similarity to BB1 and BB2.1 The affinity of BB3 for bombesin is lower than that of the BB1 and BB2 receptors, as are its affinities for NMB and GRP. This suggests that the endogenous mammalian ligand for the BB3 receptor remains to be identified.All three bombesin receptors are members of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB1 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization, and cell growth.1BB1 is expressed in the brain where it likely mediates the inhibition of food intake and regulates the stress and fear response. BB1 and its ligand NMB are expressed in the pituitary where they participate in the regulation of thyroid-stimulating hormone (TSH) secretion in both autocrine and paracrine fashions.3 In the periphery, BB1 is expressed in the gastrointestinal and urogenital smooth muscle but its physiological function in these tissues is unclear.Finally, BB1 is over-expressed in several human tumors especially colon and non-small lung cancer where it acts as a growth factor receptor inducing tumor growth. BB1 is considered a potential target for the development of both diagnostics and anti-cancer therapies.4
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基因ID
- 4829
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NCBI登录号
- NM_001324307
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UniProt
- P28336
抗原
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