Neuroligin 3 抗体 (Extracellular)
Quick Overview for Neuroligin 3 抗体 (Extracellular) (ABIN7043363)
抗原
See all Neuroligin 3 (NLGN3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 656-671, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Neuroligin 3
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-Neuroligin 3 (extracellular) Antibody (ABIN7043363, ABIN7044684 and ABIN7044685) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, analysis. The antibody recognizes an extracellular epitope, and could potentially be used for detecting the protein in living cells. It has been designed to recognize NLGN3 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)SHITRRPNGKTWSTKR, corresponding to amino acid residues 656-671 of rat NLGN3
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亚型
- IgG
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anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody
NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 unconjugated
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (HRP)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 HRP
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (FITC)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 FITC
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (Biotin)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 Biotin
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (PE)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 PE
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (APC)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 APC
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (PerCP)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 PerCP
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (Atto 488)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 Atto 488
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (Atto 594)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 Atto 594
anti-Neuroligin 3 (NLGN3) (AA 730-848) antibody (Atto 390)NLGN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S110-29 Atto 390
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7236056)
Blocking Peptide: (ABIN7236056)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Neuroligin 3 (NLGN3)
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别名
- NLGN3
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背景
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NLGN3, Gliotactin homolog, HNL3, NL3,Neuroligins (Nlgns) are a family of postsynaptic transmembrane cell adhesion proteins that play a crucial role in excitation and inhibition balance through their regulation of GABAergic and glutamatergic signaling. 5 Neuroligin family members have been identified in humans: NL1, NL2, NL3, NL4X, and NL4Y. NL 1-3 have close homologs in mice. Neurogilins have been identified in rodents, chicken, Drosophila, and C. elegans. Neuroligin structure contains extracellular acetylcholinesterase like domain that lacks esterase activity, a single transmembrane domain, and a short cytoplasmic tail containing a type I PDZ-domain-binding motif that functions in intracellular protein-protein interactions and signaling processes. Neuroligins and neurexins are known to interact with each other1,2.Neuroligin 3 is encoded by the Nlgn3 gene and seems to be ubiquitously expressed in the brain. Despite this fact, Neuroligin 3 functions in synaptic transmission appears to be region specific, affecting the somatosensory cortex and the hippocampus differently2.In humans, a missense mutation in Nlgn3 (Nlgn3R451C) causing reduced synaptic expression of the protein is associated with non-syndromic autism spectrum disorders. In addition, Nlgn3 deletion shows impaired social interaction and vocal communication in rodent models.
Alternative names: Neuroligin 3, NLGN3, Gliotactin homolog, HNL3, NL3 -
基因ID
- 171297
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NCBI登录号
- NM_018977
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UniProt
- Q62889
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途径
- Synaptic Membrane
抗原
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