Neuroligin 2 抗体 (Extracellular)
Quick Overview for Neuroligin 2 抗体 (Extracellular) (ABIN7043362)
抗原
See all Neuroligin 2 (NLGN2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 657-670, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Neuroligin 2
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特异性
- Extracellular, N-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 12,14 amino acid residues identical
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产品特性
- Anti-Neuroligin 2 (extracellular) Antibody is directed against an extracellular epitope of rat Neuroligin 2. Anti-Neuroligin 2 (extracellular) Antibody (ABIN7043362, ABIN7044682 and ABIN7044683) can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize NLGN2 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DLGPRAYDRFPGDS, corresponding to amino acid residues 657-670 of rat NLGN2
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亚型
- IgG
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anti-Neuroligin 2 (NLGN2) (Internal Region) antibody
Verified NLGN2 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Neuroligin 2 (NLGN2) (AA 15-180) antibodyNLGN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:400
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说明
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Cited Application: IP
Negative Control: (ABIN7236052)
Blocking Peptide: (ABIN7236052)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Neuroligin 2 (NLGN2)
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别名
- NLGN2
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背景
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NLGN2, NL2,Neuroligins (NLGNs) are a family of postsynaptic cell adhesion molecules that play an important role in synaptic development and function1. Four genes encode for the different members of the neuroligin family in mammals: NLGN 1-4, which are differentially enriched in postsynaptic specializations of synapses2. Neuroligin 2 (NLGN2) is expressed in neurons in the brain and also in pancreatic β cells where it facilitates insulin secretion3.Synaptic maturation is promoted by the binding of Neuroligin 2 with presynaptic Neurexins, and these interactions are restricted to particular combinations of isoforms of the binding partners3. NLGN2 plays a role in synapse function and synaptic signal transmission, especially via γ-aminobutyric acid receptors (GABA(A) receptors). NLGN2 modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing4.Recent studied identified a loss-of-function mutation of NLGN2 in schizophrenia patients, suggesting an indispensable role of NLGN2 in regulating GABAergic functions5.
Alternative names: Neuroligin 2, NLGN2, NL2 -
基因ID
- 117096
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NCBI登录号
- NM_020795
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UniProt
- Q62888
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途径
- Cell-Cell Junction Organization, Synaptic Membrane
抗原
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