Neuroligin 2 抗体 (Extracellular)
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- 抗原 See all Neuroligin 2 (NLGN2) 抗体
- Neuroligin 2 (NLGN2)
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抗原表位
- AA 657-670, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Neuroligin 2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Neuroligin 2
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Mouse - identical, human - 12,14 amino acid residues identical
- 产品特性
- Anti-Neuroligin 2 (extracellular) Antibody is directed against an extracellular epitope of rat Neuroligin 2. Anti-Neuroligin 2 (extracellular) Antibody (ABIN7043362, ABIN7044682 and ABIN7044683)) can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize NLGN2 from rat, mouse and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DLGPRAYDRFPGDS, corresponding to amino acid residues 657-670 of rat NLGN2
- 亚型
- IgG
- Top Product
- Discover our top product NLGN2 Primary Antibody
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anti-Neuroligin 2 (NLGN2) (Internal Region) antibody
Verified NLGN2 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Neuroligin 2 (NLGN2) (AA 15-180) antibodyNLGN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:400
- 说明
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Cited Application: IP
Negative Control: BLP-NR036
Blocking Peptide: BLP-NR036
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Neuroligin 2 (NLGN2)
- 别名
- NLGN2 (NLGN2 产品)
- 背景
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NLGN2, NL2,Neuroligins (NLGNs) are a family of postsynaptic cell adhesion molecules that play an important role in synaptic development and function1. Four genes encode for the different members of the neuroligin family in mammals: NLGN 1-4, which are differentially enriched in postsynaptic specializations of synapses2. Neuroligin 2 (NLGN2) is expressed in neurons in the brain and also in pancreatic β cells where it facilitates insulin secretion3.Synaptic maturation is promoted by the binding of Neuroligin 2 with presynaptic Neurexins, and these interactions are restricted to particular combinations of isoforms of the binding partners3. NLGN2 plays a role in synapse function and synaptic signal transmission, especially via γ-aminobutyric acid receptors (GABA(A) receptors). NLGN2 modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing4.Recent studied identified a loss-of-function mutation of NLGN2 in schizophrenia patients, suggesting an indispensable role of NLGN2 in regulating GABAergic functions5.
Alternative names: Neuroligin 2, NLGN2, NL2 - 基因ID
- 117096
- NCBI登录号
- NM_020795
- UniProt
- Q62888
- 途径
- Cell-Cell Junction Organization, Synaptic Membrane
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