Neuroligin 1 抗体 (Extracellular, N-Term)
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Quick Overview for Neuroligin 1 抗体 (Extracellular, N-Term) (ABIN7043361)
抗原
See all Neuroligin 1 (NLGN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 648-661, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Neuroligin 1
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,14 amino acid residues identical
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产品特性
- Anti-Neuroligin 1 (extracellular) Antibody is directed against an extracellular epitope of rat Neuroligin 1. Anti-Neuroligin 1 (extracellular) Antibody (ABIN7043361, ABIN7044680 and ABIN7044681) can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize NLGN1 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KVPSTDITLRPTRK, corresponding to amino acid residues 648-661 of rat NLGN1
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亚型
- IgG
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anti-Neuroligin 1 (NLGN1) (AA 701-800) antibody
NLGN1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuroligin 1 (NLGN1) (AA 578-677) antibodyNLGN1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Neuroligin 1 (NLGN1) (AA 718-843) antibody (Atto 390)NLGN1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S97A-31 Atto 390
anti-Neuroligin 1 (NLGN1) (AA 718-843) antibody (Atto 488)NLGN1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S97A-31 Atto 488
anti-Neuroligin 1 (NLGN1) (AA 718-843) antibody (Atto 594)NLGN1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S97A-31 Atto 594
anti-Neuroligin 1 (NLGN1) (AA 718-843) antibody (Biotin)NLGN1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S97A-31 Biotin
anti-Neuroligin 1 (NLGN1) (AA 718-843) antibody (PerCP)NLGN1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S97A-31 PerCP
anti-Neuroligin 1 (NLGN1) (AA 718-843) antibody (HRP)NLGN1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S97A-31 HRP
anti-Neuroligin 1 (NLGN1) (AA 718-843) antibody (FITC)NLGN1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S97A-31 FITC
anti-Neuroligin 1 (NLGN1) (AA 718-843) antibody (APC)NLGN1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S97A-31 APC
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应用备注
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WB: 1:800
FC: The optimal concentration should be determined by the user
ICC: 1:100
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236049)
Blocking Peptide: (ABIN7236049)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Neuroligin 1 (NLGN1)
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别名
- NLGN1
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背景
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Synonyms: NLGN1, NL1
Description: The NLGN1 gene encodes a member of a family of neuronal cell surface proteins. Neuroligins act as ligands for β-neurexins, cell adhesion proteins located presynaptically. Neuroligin and β-neurexin "shake hands," resulting in the connection between the two neurons and the production of a synapse. Neuroligin 1 may be involved in the formation and remodeling of central nervous system synapses1.Proteins of this family may also mediate signaling by recruiting and stabilizing key synaptic components. This is done by interacting with other postsynaptic proteins to localize neurotransmitter receptors and channels in the postsynaptic density as the cell matures1.Mutations in the neuroligin genes are implicated in autism and other cognitive disorders2.Neuroligins have been found to play a role in angiogenesis, specifically in human pheripheral tissues3.Neuroligins bind with the help of Ca2+ to the α-neurexin LNS (laminin, neurexin and sex hormone-binding globulin-like folding units) domains and to the β-neurexin LNS domain which then establishes a heterophilic trans-synaptic recognition code4. This binding results in a heterotetramer made up of a neuroligin-1 dimer and two neurexin-1 β monomers5.
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基因ID
- 116647
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NCBI登录号
- NM_014932
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UniProt
- Q62765
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途径
- Synaptic Membrane, Synaptic Vesicle Exocytosis
抗原
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