Neurexin 3 抗体 (Extracellular)
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- 抗原 See all Neurexin 3 (NRXN3) 抗体
- Neurexin 3 (NRXN3)
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抗原表位
- AA 39-52, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Neurexin 3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 原理
- A Rabbit Polyclonal Antibody to Neurexin 3α
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 交叉反应 （详细）
- Designed to recognize Neurexin 3α and not Neurexin 3β.
- 预测反应
- Mouse,human - identical
- 产品特性
- Anti-Neurexin 3alpha (extracellular) Antibody is directed against an epitope of rat Neurexin 3α. Anti-Neurexin 3α (extracellular) Antibody (ABIN7043359, ABIN7044678 and ABIN7044679)) can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is therefore, highly suited to recognize Nrxn3α in living cells. It has been designed to recognize Nrxn3α from rat, mouse and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RYLRWDASTRSDLS, corresponding to amino acid residues 39-52 of rat Nrxn3alpha
- 亚型
- IgG
- Top Product
- Discover our top product NRXN3 Primary Antibody
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anti-Neurexin 3 (NRXN3) (AA 1584-1643) antibody
NRXN3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (N-Term) antibodyNRXN3 适用: 人, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (Internal Region) antibodyNRXN3 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (AA 201-432) antibodyNRXN3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (AA 373-432) antibodyNRXN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 3 (NRXN3) (AA 1298-1494) antibodyNRXN3 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: BLP-NR033
Blocking Peptide: BLP-NR033
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Neurexin 3 (NRXN3)
- 别名
- NRXN3 (NRXN3 产品)
- 背景
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Nrxn3, NRX3A, Neurexin III-alpha,Neurexins (NRXNs) are a family of transmembrane, synaptic adhesion molecules. NRXNS were identified as receptors for α-latrotoxin, a presynaptic toxin that triggers massive neurotransmitter release1. Neurexins are largely presynaptic proteins that form a trans-synaptic cell-adhesion complex with postsynaptic neuroligins2. They are encoded by three genes (NRXN1, NRXN2 and NRXN3), each using an upstream promoter to produce the longer α-isoform (α-NRXNs) and a downstream promoter to generate a shorter β-isoform (β-NRXNs).The α-isoforms and β-isoforms of each neurexin are single-pass transmembrane proteins maintaining identical transmembrane and intracellular domains but having distinct extracellular domains. NRXNs in neurons localize to the presynaptic membrane and bind trans-synaptically to postsynaptic adhesion molecules and receptors3. Neurexins are expressed in all neurons, and are subject to extensive alternative splicing, generating >1,000 splice variants, some of which exhibit highly regulated developmental and spatial expression patterns4.The structure of α-Neurexins is composed of 6 LNS domains (laminin, neurexin, sex-hormone-binding protein domain) and 3 EGF-like domains. In the mammalian brain they are known to interact with neuroligins, dystroglycan and neurexophilins. Neurexin 3α splicing can give rise to secreted and transmembrane forms of the protein. The biological function of the secreted form remains unknown5.Changes in Neurexin 3α are associated with autism, drug addiction and obesity6.
Alternative names: Neurexin 3alpha, Nrxn3, NRX3A, Neurexin III-alpha - 基因ID
- 116508
- NCBI登录号
- NM_001105250
- UniProt
- Q07310
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