Neurexin 1 抗体 (Extracellular) (Atto 488)
Quick Overview for Neurexin 1 抗体 (Extracellular) (Atto 488) (ABIN7043358)
抗原
See all Neurexin 1 (NRXN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 546-560, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Neurexin 1α Conjugated to the Fluorescent Dye ATTO-488
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-Neurexin 1α (extracellular) Antibody (ABIN7043357, ABIN7044676 and ABIN7044677) is a highly specific antibody directed against an extracellular epitope of the rat protein. The antibody can be used in western blot and live cell imaging applications. It has been designed to recognize Nrxn1α from rat, mouse and human samples. \nAnti-Neurexin 1α (extracellular)- Antibody (ABIN7043358) is directly labeled with an fluorescent dye. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The label is analogous to the well known dye fluorescein isothiocyanate (FITC) and can be used with filters typically used to detect FITC. Anti-Neurexin 1α (extracellular)- Antibody has been tested in immunohistochemistry applications and is especially suited for experiments requiring simultaneous labeling of different markers.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KPRHQKDAKHPQMIK, corresponding to amino acid residues 546-560 of rat Neurexin 1alpha
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亚型
- IgG
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anti-Neurexin 1 (NRXN1) (AA 184-363) antibody
NRXN1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (C-Term) antibodyVerified NRXN1 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (N-Term) antibodyNRXN1 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 31-130) antibodyNRXN1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 31-130) antibodyNRXN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F7 unconjugated
anti-Neurexin 1 (NRXN1) (AA 31-310) antibodyNRXN1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 31-310) antibodyNRXN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 77-110), (N-Term) antibodyNRXN1 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB52794 unconjugated
anti-Neurexin 1 (NRXN1) (AA 1328-1421) antibodyNRXN1 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurexin 1 (NRXN1) (AA 546-560), (Extracellular) antibodyNRXN1 适用: 大鼠 WB, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: N/A
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说明
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Negative Control: (ABIN7582041)
Blocking Peptide: (ABIN7236037)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Neurexin 1 (NRXN1)
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别名
- NRXN1
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背景
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Nrxn1, Neurexin I-alpha,Neurexins (NRXNs) are a family of transmembrane, synaptic adhesion molecules. NRXNS were identified as receptors for α-latrotoxin, a presynaptic toxin that triggers massive neurotransmitter release1. Neurexins are largely presynaptic proteins that form a trans-synaptic cell-adhesion complex with postsynaptic neuroligins2. They are encoded by three genes (NRXN1, NRXN2 and NRXN3), each using an upstream promoter to produce the longer α-isoform (α-NRXNs) and a downstream promoter to generate a shorter β-isoform (β- NRXNs).The α- and β-isoforms of each neurexin are single-pass transmembrane proteins maintaining identical transmembrane and intracellular domains but having distinct extracellular domains. NRXNs in neurons localize to the presynaptic membrane and bind trans-synaptically to postsynaptic adhesion molecules and receptors3. Neurexins are expressed in all neurons, and are subject to extensive alternative splicing, generating >1,000 splice variants, some of which exhibit highly regulated developmental and spatial expression patterns4. The extracellular domain of neurexin 1α (NRXN1α) is composed of three neurexin repeats (I, II, and III), which each contains the modules LNS-EGF-LNS. NRXN1α binds endogenous ligands including neuroligins, LRRTM family members, neurexophilin, α-dystroglycan, and GABA(A) receptors.NRXN1α gene mutations have been identified in neuropsychiatric diseases including Schizophrenia and Autism Spectrum Disorder5.
Alternative names: Neurexin 1alpha, Neurexin I-alpha, Nrxn1 -
基因ID
- 60391
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NCBI登录号
- NM_001135659
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UniProt
- Q63372
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途径
- Synaptic Membrane, Skeletal Muscle Fiber Development
抗原
-
