MRS2 抗体 (Mitochondrial Matrix)
Quick Overview for MRS2 抗体 (Mitochondrial Matrix) (ABIN7043335)
抗原
See all MRS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 211-223, Mitochondrial Matrix
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原理
- A Rabbit Polyclonal Antibody to MRS2 Magnesium Transporter
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特异性
- N-terminus, mitochondrial matrix.
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-MRS2 Antibody is directed against an epitope of the rat MRS2 magnesium transporter. Anti-MRS2 Antibody (ABIN7043335, ABIN7044851 and ABIN7044852) can be used in western blot analysis. It has been designed to recognize MRS2 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DPKHSSVDRSKLH, corresponding to amino acid residues 211-223 of rat MRS2 magnesium transporter
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亚型
- IgG
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anti-MRS2 Magnesium Homeostasis Factor Homolog (MRS2) (AA 201-300) antibody
MRS2 适用: 大鼠, 小鼠 WB, IF (cc), IF (p), ELISA, IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-MRS2 Magnesium Homeostasis Factor Homolog (MRS2) (AA 1-117) antibodyMRS2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1E2 unconjugated
anti-MRS2 Magnesium Homeostasis Factor Homolog (MRS2) (AA 215-264) antibodyMRS2 适用: 大鼠, 小鼠, 人, Cow, 马, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-MRS2 Magnesium Homeostasis Factor Homolog (MRS2) (Middle Region) antibodyMRS2 适用: 大鼠, 小鼠, 人 WB 宿主: 兔 Polyclonal unconjugated
anti-MRS2 Magnesium Homeostasis Factor Homolog (MRS2) (Middle Region) antibodyMRS2 适用: 大鼠, 小鼠, 人, Cow, 马, Pig, 犬, 山羊, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:400
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说明
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Negative Control: (ABIN7235967)
Blocking Peptide: (ABIN7235967)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- MRS2 (MRS2 Magnesium Homeostasis Factor Homolog (MRS2))
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别名
- MRS2
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背景
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MRS2 magnesium transporter, Magnesium transporter MRS2 homolog mitochondrial, MRS2-like protein, MRS2L,Magnesium is one of the most abundant cation in the cell. It is crucial for the proper functioning of various tissues such as the brain, muscle, bone and the nervous system. Currently there are only two types of Mg2+ transport systems which have had their complete structures discovered. MgtE and CorA are the prokaryotic homologues of the SLC41 and MRS2 magnesium transporters.In eukaryotes, MRS2 protein is expressed in mitochondrial inner membranes. MRS2 is required for normal mitochondrial magnesium homeostasis and for proper myelination in the central nervous system. Notably, the expression of MRS2 serves as a genetic hallmark for embryonic stem cells2.MRS2 is comprised of two adjacent transmembrane domains. The first domain ends with a gly-met-asn motif and additional secondary structures. A long N-terminal and a short C-terminal sequence are located in the inner side of the mitochondrial membrane leaving the short loop connecting the transmembrane domains protruding to its exterior.In addition to its Mg2+ permeability, MRS2 transporters somewhat transport Ni2+. However, they are not permeable to Ca2+, Mn2+ and Co2+. MRS2 transporters can be blocked by Cobalt(III)-hexaamine, an analog of the hydrated Mg2+ ion and their activity is regulated by matrix Mg2+ concentrations. Increase in Mg2+ concentration causes a shift of the current-voltage relationship to a more negative potential as expected from the reduction in driving force and significantly reduces the channels' open-time probability2.Several SNPs in the MRS2 gene are associated an increased risk of developing type 2 diabetes in women of African American and Hispanic American origin3.
Alternative names: MRS2, MRS2 magnesium transporter, Magnesium transporter MRS2 homolog mitochondrial, MRS2-like protein, MRS2L -
基因ID
- 79032
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NCBI登录号
- NM_001286264
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UniProt
- Q9ET09
抗原
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