Melatonin Receptor 1B 抗体 (AA 232-246)
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- 抗原 See all Melatonin Receptor 1B (MTNR1B) 抗体
- Melatonin Receptor 1B (MTNR1B)
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抗原表位
- AA 232-246
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Melatonin Receptor 1B antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)
- 原理
- A Rabbit Polyclonal Antibody to Melatonin Receptor Type 1B
- 特异性
- 3rd intracellular loop
- 交叉反应
- 小鼠, 大鼠
- 交叉反应 （详细）
- Unlikely to recognize human samples.
- 预测反应
- Rat - 14,15 amino acid residues identical
- 产品特性
- Anti-Melatonin Receptor 1B (MTNR1B) Antibody (ABIN7043327, ABIN7044601 and ABIN7044602)) is a highly specific antibody directed against an epitope of mouse MT2. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize MT2 from rat and mouse samples. The antibody is unlikely to recognize the receptor in human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RKAKATRKLRLRPSD, corresponding to amino acid residues 232-246 of mouse MTNR1B
- 亚型
- IgG
- Top Product
- Discover our top product MTNR1B Primary Antibody
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anti-Melatonin Receptor 1B (MTNR1B) (AA 201-300) antibody
MTNR1B 适用: 人, 小鼠, 大鼠, 山羊 ELISA, WB, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1B (MTNR1B) (AA 1-42) antibodyMTNR1B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1B (MTNR1B) (C-Term) antibodyMTNR1B 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1B (MTNR1B) (Extracellular Domain) antibodyMTNR1B 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1B (MTNR1B) (N-Term) antibodyMTNR1B 适用: 人, 大鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1B (MTNR1B) antibodyMTNR1B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1B (MTNR1B) (N-Term) antibodyMTNR1B 适用: 人, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:600-1:2000
Application Dilutions Western blot wb: 1:200
- 说明
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Cited Application: IHC|ICC
Negative Control: BLP-MR032
Blocking Peptide: BLP-MR032
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Melatonin Receptor 1B (MTNR1B)
- 别名
- MTNR1B (MTNR1B 产品)
- 背景
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Melatonin receptor type 2, MT2, Mel1b receptor, Mel-1B-R,Melatonin (N-acetyl-5-methoxytryptamine) is a product of tryptophan metabolism. It is synthesized in the pineal gland and is secreted to control the circadian rhythm1-3. Melatonin is also synthesized in the gastrointestinal tract, retina, skin and other tissues where it acts in a autocrine or paracrine manner. The role of melatonin in these tissues is independent of its role in the circadian rhythm, where it plays a role in energy metabolism, physiological growth, differentiation and responsiveness in stress stimuli1. The pleiotropic effects of melatonin have given rise to various therapeutic possibilities for this molecule. For example, anti-stress, sexual dysfunction, obesity, gallbladder stones1,4. To date, the only therapeutic uses for melatonin remain to treat sleep disorders, depression, migraine and headaches1.Melatonin exerts its effects through two G-protein coupled receptors (GPCRs), melatonin receptor type 1 and melatonin receptor type 2 (MT1 and MT2). Like all GPCRs, they have seven transmembrane domains and extracellular N-terminal and cytoplasmic C-terminal tails. The binding of melatonin to either receptor activates Gi, thereby activating PLC, thus increasing intracellular Ca2+ levels. Both receptors structurally bind melatonin in the same manner, although MT2 displays a much higher affinity for the hormone. Just like melatonin levels are detected in many tissues, the expression patterns of the two receptors are also quite broad. For example, MT1 is detected in the brain, retina and kidneys and MT2 is expressed in brain and in the retina1.MT1 is involved in sleep regulation and might also have effects on peripheral vasoconstriction. MT2 may play an important physiological role in the retina and might regulate body temperature1.
Alternative names: Melatonin Receptor 1B (MTNR1B), Melatonin receptor type 2, MT2, Mel1b receptor, Mel-1B-R - 基因ID
- 244701
- NCBI登录号
- NM_005959
- UniProt
- Q8CIQ6
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