Melatonin Receptor 1A 抗体 (AA 223-236)
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- 抗原 See all Melatonin Receptor 1A (MTNR1A) 抗体
- Melatonin Receptor 1A (MTNR1A)
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抗原表位
- AA 223-236
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Melatonin Receptor 1A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)
- 原理
- A Rabbit Polyclonal Antibody to Melatonin Receptor Type 1A
- 特异性
- 3rd intracellular loop
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Rat,human - 13,14 amino acid residues identical
- 产品特性
- Anti-Melatonin Receptor 1A (MTNR1A) Antibody (ABIN7043326, ABIN7044599 and ABIN7044600)) is a highly specific antibody directed against an epitope of mouse MT1. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize MT1 from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RVKPDNKPKLKPQD, corresponding to amino acid residues 223-236 of mouse MTNR1A
- 亚型
- IgG
- Top Product
- Discover our top product MTNR1A Primary Antibody
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anti-Melatonin Receptor 1A (MTNR1A) (AA 296-350) antibody
MTNR1A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1A (MTNR1A) (AA 201-280) antibodyMTNR1A 适用: 人, 小鼠, 大鼠, Cow WB, ELISA, FACS, IF (p), IHC (p), IHC (fro), DB 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1A (MTNR1A) (AA 300-353) antibodyMTNR1A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1A (MTNR1A) (AA 281-350) antibodyMTNR1A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1A (MTNR1A) (AA 296-350) antibodyMTNR1A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Melatonin Receptor 1A (MTNR1A) (AA 209-239) antibodyMTNR1A 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB23653 unconjugated
anti-Melatonin Receptor 1A (MTNR1A) (AA 296-350) antibodyMTNR1A 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 1# unconjugated
anti-Melatonin Receptor 1A (MTNR1A) (AA 312-366) antibodyMTNR1A 适用: 山羊 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1A (MTNR1A) (Cytoplasmic Domain) antibodyMTNR1A 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Melatonin Receptor 1A (MTNR1A) (AA 191-240) antibodyMTNR1A 适用: 人, 小鼠, 大鼠 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- 说明
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Cited Application: IHC
Negative Control: BLP-MR031
Blocking Peptide: BLP-MR031
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Melatonin Receptor 1A (MTNR1A)
- 别名
- MTNR1A (MTNR1A 产品)
- 背景
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MT1, Mel1a receptor, Mel-1A-R,Melatonin (N-acetyl-5-methoxytryptamine) is a product of tryptophan metabolism. It is synthesized in the pineal gland and is secreted to control the circadian rhythm1-3. Melatonin is also synthesized in the gastrointestinal tract, retina, skin and other tissues where it acts in a autocrine or paracrine manner. The role of melatonin in these tissues is independent of its role in the circadian rhythm, where it plays a role in energy metabolism, physiological growth, differentiation and responsiveness in stress stimuli1. The pleiotropic effects of melatonin have given rise to various therapeutic possibilities for this molecule. For example, anti-stress, sexual dysfunction, obesity, gallbladder stones1,4. To date, the only therapeutic uses for melatonin remain to treat sleep disorders, depression, migraine and headaches1.Melatonin exerts its effects through two G-protein coupled receptors (GPCRs), melatonin receptor type 1 and melatonin receptor type 2 (MT1 and MT2). Like all GPCRs, they have seven transmembrane domains and extracellular N-terminal and cytoplasmic C-terminal tails. The binding of melatonin to either receptor activates Gi, thereby activating PLC, thus increasing intracellular Ca2+ levels. Both receptors structurally bind melatonin in the same manner, although MT2 displays a much higher affinity for the hormone. Just like melatonin levels are detected in many tissues, the expression patterns of the two receptors are also quite broad. For example, MT1 is detected in the brain, retina and kidneys and MT2 is expressed in brain and in the retina1.MT1 is involved in sleep regulation and might also have effects on peripheral vasoconstriction. MT2 may play an important physiological role in the retina and might regulate body temperature1.
Alternative names: Melatonin Receptor 1A (MTNR1A), MT1, Mel1a receptor, Mel-1A-R - 基因ID
- 17773
- NCBI登录号
- NM_005958
- UniProt
- Q61184
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