MAGT1 抗体 (Extracellular)
Quick Overview for MAGT1 抗体 (Extracellular) (ABIN7043318)
抗原
See all MAGT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 28-40, Extracellular
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原理
- A Rabbit Polyclonal antibody to MAGT1 (extracellular) magnesium transporter.
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特异性
- Extracellular, N-terminus.
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交叉反应
- 人, 小鼠, 大鼠
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交叉反应 （详细）
- The immunizing peptide bears some homology (7 out of 13 amino acid residues) with the related protein TUSC3 (Accession Q13454).
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预测反应
- Mouse - identical Rat 11 out of 13 amino acid residues identical
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产品特性
- Anti-MAGT1 (extracellular) Antibody (ABIN7043318, ABIN7044863 and ABIN7044864) is a highly specific antibody directed against an extracellular epitope of the human protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize MAGT1 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)SAQRKKEMVLSEK, corresponding to amino acid residues 28-40 of human MAGT1
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亚型
- IgG
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anti-Magnesium Transporter 1 (MAGT1) (AA 35-84) antibody
MAGT1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Magnesium Transporter 1 (MAGT1) (AA 44-71), (N-Term) antibodyMAGT1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB25786 unconjugated
anti-Magnesium Transporter 1 (MAGT1) (N-Term) antibodyMAGT1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Magnesium Transporter 1 (MAGT1) (AA 44-71), (N-Term) antibodyMAGT1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7235907)
Blocking Peptide: (ABIN7235907)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- MAGT1 (Magnesium Transporter 1 (MAGT1))
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别名
- MAGT1
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背景
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Magnesium Transporter 1, Oligosaccharyl Transferase Subunit MAGT1, Implantation-Associated Protein, SLC58A1,Magnesium Transporter 1 (MAGT1) is a 335 amino acid peptide that is a part of the MAGT group of magnesium transporters. Magnesium (Mg2+) plays an essential cellular role, as a cofactor for ATP, nucleic acids, and numerous enzymes. It has been reported that it serves as a second messenger in intracellular signaling, and hence magnesium levels maintenance has a vast effect on cellular steady state 1. In addition to its Mg2+ transporter activity, MAGT1 was also found to be a subunit of the oligosaccharyltransferase (OST) complex, through which it is responsible for protein glycosylation 2,3.MAGT1 was shown to be related to the development of XMEN (X-linked immunodeficiency with magnesium defect, Epstein Barr Virus infection, and neoplasia) syndrome, for which Mg2+ supplementation has been shown to be beneficial. It is also related to atypical ATRX syndrome, intellectual disability and skin abnormalities.Understanding the molecular basis of the involvement of magnesium and its channels in human pathogenesis can lead to the development of new medications for many diseases.
Alternative names: Magnesium Transporter 1, Oligosaccharyl Transferase Subunit MAGT1, Implantation-Associated Protein, SLC58A1 -
基因ID
- 84061
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NCBI登录号
- NM_032121
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UniProt
- Q9H0U3
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途径
- Cell RedoxHomeostasis
抗原
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