LPAR6 抗体 (2nd Extracellular Loop)
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北京 101111
Quick Overview for LPAR6 抗体 (2nd Extracellular Loop) (ABIN7043317)
抗原
See all LPAR6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Extracellular Loop, AA 156-168
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原理
- A Rabbit Polyclonal Antibody to LPA Receptor 6 (P2RY5)
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,mouse -12,13 amino acid residues identical
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产品特性
- Anti-LPAR6 (P2RY5) (extracellular) Antibody is directed against an epitope of the human LPA receptor 6. Anti-LPAR6 (P2RY5) (extracellular) Antibody (ABIN7043317, ABIN7044576 and ABIN7044577) can be used in western blot analysis. The antibody recognizes an extracellular epitope and is thus ideal for detecting the receptor in living cells. It has been designed to recognize LPA receptor 6 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- STHSQGNNASEAC, corresponding to amino acid residues 156-168 of human LPA receptor 6
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亚型
- IgG
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anti-Lysophosphatidic Acid Receptor 6 (LPAR6) (AA 106-134) antibody
LPAR6 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB32125 unconjugated
anti-Lysophosphatidic Acid Receptor 6 (LPAR6) (Internal Region) antibodyLPAR6 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 6 (LPAR6) (AA 292-313) antibodyLPAR6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 6 (LPAR6) (AA 113-142), (Middle Region) antibodyLPAR6 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235906)
Blocking Peptide: (ABIN7235906)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- LPAR6 (Lysophosphatidic Acid Receptor 6 (LPAR6))
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别名
- LPAR6
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背景
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Synonyms: Lysophosphatidic acid receptor 6, LPA receptor 6, LPA-6, P2Y purinoceptor 5, Purinergic receptor 5, P2Y5, RB intron encoded G-protein coupled receptor
Description: Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol-3-phosphate) is a bioactive lipid molecule with a phosphate, a glycerol, and a fatty acid in its structure. The cellular effects of LPA include proliferation, migration, cytokine secretion, and morphological change. These pleiotropic actions allow LPA to participate in a wide variety of biological processes, such as brain development, oncogenesis, wound healing and cancer progression1. To date, at least 6 subtypes of LPA receptor have been identified. The LPA1-3 receptors are members of the endothelial cell differentiation gene (Edg) family2.LPA6 (P2Y5) was cloned as an orphan GPCR and is closely related to the fourth lysophosphatidic acid receptor, LPA43. GPCRs share a similar topology, with seven transmembrane helices (TMHs) connected by three extracellular loops (ECLs), and three intracellular loops (ICLs), the N terminus is on the extracellular side of the membrane, and the C terminus is on the cytoplasmic side4.LPA6 mRNA is expressed ubiquitously including in skin and hair follicle cells.A recent study suggested that LPA6 is essential for human hair growth. A loss of function is not compensated for, and ultimately leads to pathological changes and hair loss5.
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基因ID
- 10161
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NCBI登录号
- NM_005767
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UniProt
- P43657
抗原
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