EDG4 抗体 (Extracellular, N-Term) (FITC)
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Quick Overview for EDG4 抗体 (Extracellular, N-Term) (FITC) (ABIN7043313)
抗原
See all EDG4 (LPAR2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 16-29, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to LPA Receptor 2 (EDG4) Conjugated to the Fluorescent Dye FITC
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat - identical, human - 13,14 amino acid residues identical
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产品特性
- Anti-LPAR2 (EDG4) (extracellular) Antibody (ABIN7043312, ABIN7044568 and ABIN7044569) is a highly specific antibody directed against an epitope of the mouse LPA2 receptor. The antibody can be used in western blot analysis. It recognizes an extracellular epitope and thus is ideal for detecting the receptor in living cells. It has been designed to recognize LPA2 receptor from human, rat, and mouse samples. \nAnti-LPAR2 (EDG4) (extracellular)-FITC Antibody (ABIN7043312, ABIN7044568 and ABIN7044569)-F) is directly conjugated to fluorescein isothiocyanate (FITC). The antibody can be used in immunofluorescent applications such as direct live cell flow cytometry.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)NSGKELSLHWRPKD, corresponding to amino acid residues 16-29 of mouse LPA2 receptor
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亚型
- IgG
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anti-Lysophosphatidic Acid Receptor 2 (LPAR2) (AA 3-32), (N-Term) antibody
LPAR2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1827 unconjugated
anti-Lysophosphatidic Acid Receptor 2 (LPAR2) (Cytoplasmic Domain) antibodyLPAR2 适用: 人 IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 2 (LPAR2) (AA 1-100) antibodyLPAR2 适用: 小鼠, 大鼠 ELISA, IF (p), FACS, IHC (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 2 (LPAR2) (AA 8-27) antibodyLPAR2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 2 (LPAR2) antibodyLPAR2 适用: 人, 小鼠, 大鼠 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 2 (LPAR2) (C-Term) antibodyLPAR2 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 2 (LPAR2) (AA 250-350) antibodyLPAR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 2 (LPAR2) antibodyLPAR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 2 (LPAR2) (AA 290-339) antibodyLPAR2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 2 (LPAR2) (AA 271-320) antibodyLPAR2 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: The optimal concentration should be determined by the user
FC: 2.5-5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7235902)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))
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别名
- LPAR2
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背景
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Synonyms: Lysophosphatidic acid receptor 2, LPA receptor 2, LPA-2
Description: Lysophosphatidic acid (LPA) is a lipid mediator that induces various cellular responses including proliferation, migration and inhibition of apoptosis in numerous types of cells via its specific G protein-coupled receptors. At least 5 LPA G-protein coupled receptors (GPCRs) have been identified so far. LPA mediates its effects predominantly by interacting with members of the endothelial differentiation gene (EDG) subfamily of GPCRs: LPA1/EDG2, LPA2/EDG4, and LPA3/EDG71. LPA2 couples to three distinct families of heterotrimeric GTP binding proteins, including Gαq, Gαi, and Gα12/132.LPA2 spans the plasma membrane seven times and contains three extracellular loops and three intracellular loops. LPA2 is unique from the other LPA receptors as it contains two distinct protein-protein interaction domains in the carboxyl-terminal tail (aa 296-351). In the proximal region, LPA2 contains a di-leucine motif and several putative palmitoylated cysteine residues. This region is responsible for associating with zinc-finger proteins3.LPA2 mRNA is expressed in a variety of tissues including human testis, leukocytes, prostate, spleen, thymus, pancreas, and bone marrow3.LPA2-null mice do not show any obvious phenotypic aberrations5. On the other hand, LPA2 expression is increased in ovarian and thyroid cancers and inflammation, suggesting that the main function of LPA2 could become evident under pathophysiological conditions6.
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基因ID
- 53978
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NCBI登录号
- NM_004720
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UniProt
- Q9JL06
抗原
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