LYNX1 抗体 (Extracellular, N-Term)
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Quick Overview for LYNX1 抗体 (Extracellular, N-Term) (ABIN7043310)
抗原
See all LYNX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 26-38, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Lynx1
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- rat - 12,Mouse,13 amino acid residues identical, human - 11
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产品特性
- Anti-Lynx1 (extracellular) Antibody (ABIN7043310, ABIN7044635 and ABIN7044636) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, indirect live cell flow cytometry, and immunohistochemistry applications. It has been designed to recognize Lynx1 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CAYNGDN(S)FKPMR, corresponding to amino acid residues 26-38 of mouse Lynx1
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亚型
- IgG
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anti-Ly6/Neurotoxin 1 (LYNX1) (AA 40-89) antibody
LYNX1 适用: 小鼠, 人, 大鼠, Cow, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ly6/Neurotoxin 1 (LYNX1) (Middle Region) antibodyLYNX1 适用: 小鼠, 人, 大鼠, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:1000
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235894)
Blocking Peptide: (ABIN7235894)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- LYNX1 (Ly6/Neurotoxin 1 (LYNX1))
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别名
- LYNX1
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背景
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Synonyms: Ly-6/Neurotoxin-like protein 1, Endogenous prototoxin LYNX1
Description: Lynx1 is a member of the Ly-6/neurotoxin gene superfamily (Lynx family) of proteins that feature a three-looped toxin fold and a cysteine rich motif, structural characteristics that are shared with the snake venom toxin α-bungarotoxin1.Lynx1 is expressed in large projection neurons in the hippocampus, cortex, and cerebellum. Initial analysis of the functional consequence of genetic ablation of Lynx1 in mice revealed that Lynx1 is an allosteric modulator of various nicotinic receptors that affects their kinetics, decreases their agonist affinities, and increases their desensitization to overall limit their activation. Lynx1 can serve as a protective measure against neurotoxicity through agonist-induced overstimulation2. In fact, deletion of Lynx1 eventually leads to neurodegeneration in aged mice3.Collectively the findings regarding Lynx1 suggest a direct relationship between plasticity regulation and nicotinic signaling, and underline the significance of fine tuning of nicotinic tone to vastly control the development of brain functions.Lynx1 activity was shown to be related to the pathophysiology of Alzheimer's disease as well as cholinergic activity in healthy and tumor cells of bronchial epithelium4.
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基因ID
- 23936
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NCBI登录号
- NM_177476
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UniProt
- P0DP60
抗原
-
