LYNX1 抗体 (Extracellular)
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- 抗原 See all LYNX1 抗体
- LYNX1 (Ly6/Neurotoxin 1 (LYNX1))
- 抗原表位
- AA 26-38, Extracellular
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LYNX1 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (IHC)
- 原理
- A Rabbit Polyclonal Antibody to Lynx1
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- rat - 12,Mouse,13 amino acid residues identical, human - 11
- 产品特性
- Anti-Lynx1 (extracellular) Antibody (ABIN7043310, ABIN7044635 and ABIN7044636)) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, indirect live cell flow cytometry, and immunohistochemistry applications. It has been designed to recognize Lynx1 from rat, mouse, and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CAYNGDN(S)FKPMR, corresponding to amino acid residues 26-38 of mouse Lynx1
- 亚型
- IgG
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anti-Ly6/Neurotoxin 1 (LYNX1) (AA 40-89) antibody
LYNX1 适用: 小鼠, Cow, 豚鼠, 人, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ly6/Neurotoxin 1 (LYNX1) (Middle Region) antibodyLYNX1 适用: 小鼠, Cow, 豚鼠, 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:1000
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: BLP-NC021
Blocking Peptide: BLP-NC021
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- LYNX1 (Ly6/Neurotoxin 1 (LYNX1))
- 别名
- LYNX1 (LYNX1 产品)
- 背景
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Ly-6/Neurotoxin-like protein 1, Endogenous prototoxin LYNX1,Lynx1 is a member of the Ly-6/neurotoxin gene superfamily (Lynx family) of proteins that feature a three-looped toxin fold and a cysteine rich motif, structural characteristics that are shared with the snake venom toxin α-bungarotoxin1.Lynx1 is expressed in large projection neurons in the hippocampus, cortex, and cerebellum. Initial analysis of the functional consequence of genetic ablation of Lynx1 in mice revealed that Lynx1 is an allosteric modulator of various nicotinic receptors that affects their kinetics, decreases their agonist affinities, and increases their desensitization to overall limit their activation. Lynx1 can serve as a protective measure against neurotoxicity through agonist-induced overstimulation2. In fact, deletion of Lynx1 eventually leads to neurodegeneration in aged mice3.Collectively the findings regarding Lynx1 suggest a direct relationship between plasticity regulation and nicotinic signaling, and underline the significance of fine tuning of nicotinic tone to vastly control the development of brain functions.Lynx1 activity was shown to be related to the pathophysiology of Alzheimer's disease as well as cholinergic activity in healthy and tumor cells of bronchial epithelium4.
Alternative names: Ly-6/Neurotoxin-like protein 1, Endogenous prototoxin LYNX1 - 基因ID
- 23936
- NCBI登录号
- NM_177476
- UniProt
- P0DP60
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