KCNIP2 抗体 (Cytosolic, N-Term)
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Quick Overview for KCNIP2 抗体 (Cytosolic, N-Term) (ABIN7043296)
抗原
See all KCNIP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-15, Cytosolic, N-Term
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原理
- A Rabbit Polyclonal Antibody to KChIP2 Subunit
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical Rat - 13,14 amino acid residues identical
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产品特性
- Anti-KChIP2 Antibody (ABIN7043296, ABIN7045040 and ABIN7045041) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize KChIP2 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RGQGRKESLSDSRD, corresponding to amino acid residues 2-15 of human KChIP2
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亚型
- IgG
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anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 78-112), (N-Term) antibody
KCNIP2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (N-Term) antibodyKCNIP2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, Cow, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 1-100) antibodyKCNIP2 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) antibodyMicroarray verified KCNIP2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB734458 unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) antibodyMicroarray verified KCNIP2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB191722 unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) antibodyMicroarray verified KCNIP2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB488277 unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 1-270) antibodyKCNIP2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 1-270) antibodyKCNIP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 1-90) antibodyKCNIP2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 1-90) antibodyKCNIP2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:400
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IP|ICC
Negative Control: (ABIN7235841)
Blocking Peptide: (ABIN7235841)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- KCNIP2 (Kv Channel Interacting Protein 2 (KCNIP2))
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别名
- KCNIP2
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背景
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Synonyms: KCNIP2, KV channel-interacting protein 2, A-type potassium channel modulatory protein 2, Cardiac voltage-gated potassium channel modulatory subunit
Description: KChIPs belong to the family of small cytosolic calcium-binding proteins and consist of four different KChIP isoforms ranging between 216 and 270 amino acids. They all have a reasonably conserved core region of 185 amino acids and a heterogeneous N-terminal. KChIPs have calcium-binding EF hands which appear to be important for modulation of KV channels but not for CaV channels1.The cardiac KChIP2 gene generates three protein isoforms of 220, 252, and 270 amino acids via alternative splicing of exons 2 and 3. It is well established that KChIP2 functionally increases peak KV4 current, slows channel inactivation and accelerates recovery from inactivation. Furthermore, KChIP2 has been reported to increase ICa,L and suggested to decrease KV1.5 cell surface expression and facilitate INa2 .All four KChIP mRNAs are found in the brain, however only KChIP2 is expressed in the heart3. KChIP2 is expressed heterogeneously across the canine and human left and right ventricular free wall with higher concentrations in epicardium compared to endocardium4.Mice deficient for KChIP2 exhibit normal cardiac structure and function but display a prolonged elevation in the ST segment on the electrocardiogram. The KChIP2-/- mice are highly susceptible to the induction of cardiac arrhythmias5.
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基因ID
- 30819
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NCBI登录号
- NM_014591
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UniProt
- Q9NS61
抗原
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