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- 抗原 See all KCNIP2 抗体
- KCNIP2 (Kv Channel Interacting Protein 2 (KCNIP2))
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抗原表位
- AA 2-15, Cytosolic
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KCNIP2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 原理
- A Rabbit Polyclonal Antibody to KChIP2 Subunit
- 特异性
- Cytoplasmic, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse - identical Rat - 13,14 amino acid residues identical
- 产品特性
- Anti-KChIP2 Antibody (ABIN7043296, ABIN7045040 and ABIN7045041) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize KChIP2 from rat, mouse, and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RGQGRKESLSDSRD, corresponding to amino acid residues 2-15 of human KChIP2
- 亚型
- IgG
- Top Product
- Discover our top product KCNIP2 Primary Antibody
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anti-Kv Channel Interacting Protein 2 (KCNIP2) (N-Term) antibody
KCNIP2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, Cow, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 1-100) antibodyKCNIP2 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) antibodyMicroarray verified KCNIP2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB734458 unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) antibodyMicroarray verified KCNIP2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB488277 unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) antibodyMicroarray verified KCNIP2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB191722 unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 1-270) antibodyKCNIP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 1-270) antibodyKCNIP2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 1-90) antibodyKCNIP2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) (AA 1-90) antibodyKCNIP2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 2 (KCNIP2) antibodyMicroarray verified KCNIP2 适用: 人 IHC 宿主: 小鼠 Monoclonal MAB417991 unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400
Application Dilutions Western blot wb: 1:200
- 说明
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Cited Application: IP|ICC
Negative Control: (ABIN7235841)
Blocking Peptide: (ABIN7235841)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- KCNIP2 (Kv Channel Interacting Protein 2 (KCNIP2))
- 别名
- KCNIP2 (KCNIP2 产品)
- 背景
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KCNIP2, KV channel-interacting protein 2, A-type potassium channel modulatory protein 2, Cardiac voltage-gated potassium channel modulatory subunit,KChIPs belong to the family of small cytosolic calcium-binding proteins and consist of four different KChIP isoforms ranging between 216 and 270 amino acids. They all have a reasonably conserved core region of 185 amino acids and a heterogeneous N-terminal. KChIPs have calcium-binding EF hands which appear to be important for modulation of KV channels but not for CaV channels1.The cardiac KChIP2 gene generates three protein isoforms of 220, 252, and 270 amino acids via alternative splicing of exons 2 and 3. It is well established that KChIP2 functionally increases peak KV4 current, slows channel inactivation and accelerates recovery from inactivation. Furthermore, KChIP2 has been reported to increase ICa,L and suggested to decrease KV1.5 cell surface expression and facilitate INa2 .All four KChIP mRNAs are found in the brain, however only KChIP2 is expressed in the heart3. KChIP2 is expressed heterogeneously across the canine and human left and right ventricular free wall with higher concentrations in epicardium compared to endocardium4.Mice deficient for KChIP2 exhibit normal cardiac structure and function but display a prolonged elevation in the ST segment on the electrocardiogram. The KChIP2-/- mice are highly susceptible to the induction of cardiac arrhythmias5.
Alternative names: KChlP2, KCNIP2, KV channel-interacting protein 2, A-type potassium channel modulatory protein 2, Cardiac voltage-gated potassium channel modulatory subunit - 基因ID
- 30819
- NCBI登录号
- NM_014591
- UniProt
- Q9NS61
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