KCNIP1 抗体 (AA 10-21)
Quick Overview for KCNIP1 抗体 (AA 10-21) (ABIN7043295)
抗原
See all KCNIP1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 10-21
-
原理
- A Rabbit Polyclonal Antibody to KChIP1 Subunit
-
特异性
- N-terminal domain
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Mouse,human - identical
-
产品特性
- Anti-KChIP1 (KCNIP1) Antibody is directed against an epitope of rat KChIP1. Anti-KChIP1 (KCNIP1) Antibody (ABIN7043295 and ABIN7045039) can be used for western blot analysis. It has been designed to recognize KChIP1 from human mouse and rat samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)SLQTKQRRPSKD, corresponding to amino acid residues 10-21 of rat KChIP1
-
亚型
- IgG
-
-
anti-Kv Channel Interacting Protein 1 (KCNIP1) (AA 1-216) antibody
KCNIP1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-Kv Channel Interacting Protein 1 (KCNIP1) antibodyKCNIP1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 1 (KCNIP1) (N-Term) antibodyKCNIP1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 小鸡, 猴, Pig, 非洲爪蟾 IHC, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 1 (KCNIP1) (C-Term) antibodyKCNIP1 适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 1 (KCNIP1) antibodyKCNIP1 适用: 人 WB 宿主: 小鼠 Monoclonal 6C239-4 unconjugated
anti-Kv Channel Interacting Protein 1 (KCNIP1) (AA 11-28) antibodyKCNIP1 适用: 人, 小鼠, Cow, 小鸡, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 1 (KCNIP1) (N-Term) antibodyKCNIP1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 犬, 兔 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Kv Channel Interacting Protein 1 (KCNIP1) antibodyKCNIP1 适用: 大鼠 IHC, WB 宿主: 小鼠 Monoclonal S55-82 unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
-
说明
-
Cited Application: IP
Negative Control: (ABIN7235837)
Blocking Peptide: (ABIN7235837)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- KCNIP1 (Kv Channel Interacting Protein 1 (KCNIP1))
-
别名
- KCNIP1
-
背景
-
KV channel-interacting protein 1, VABP, Vesicle APC-binding protein, A-type potassium channel modulatory protein 1, Potassium channel-interacting protein 1,Voltage-gated K+ (KV) channels form functional entities by the assembly of four α subunits and auxiliary subunits. Various auxiliary subunits are known to interact with KV channels thereby modulating various properties such as gating, activation and inactivation of the channels as well as influencing trafficking of the channels to the cell's plasma membrane1.KChIPs (KV channel interacting proteins) are cytoplasmic proteins which belong to the neural Ca2+ sensor (NCS) family of Ca2+ binding EF-hand proteins. To date, KChIP1-4 have been identified. All four KChIPs have a conserved C-terminal domain, which has four EF-hand-like Ca2+ binding motifs. The N-terminal region differs among the various KChIPs and attributes different properties regarding the regulation of KV channels1. KChIPs regulate different properties of KV channels such as their cell surface expression (mediated by proper trafficking of the various subunits), channel assembly and gating1-4. Specifically, KChIP1 strongly regulates the activity of the KV4 channel family1. KChIP1 has also been found to assist GABA-mediated IPSCs (inhibitory postsynaptic currents) by increasing the release of presynaptic transmitter5. Furthermore, KChIP knockout mice display an increase in anxiety-like behavior compared to their wild type counterparts5.KChIP1, 3, and 4 are mostly expressed in the brain while KChIP2 is expressed in the heart as well as in the brain4-6.
Alternative names: KChIP1 (KCNIP1), KV channel-interacting protein 1, VABP, Vesicle APC-binding protein, A-type potassium channel modulatory protein 1, Potassium channel-interacting protein 1 -
基因ID
- 65023
-
NCBI登录号
- NM_001278339
-
UniProt
- Q8R426
抗原
-
