HOMER3 抗体 (Intracellular)
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- 抗原 See all HOMER3 抗体
- HOMER3 (Homer Homolog 3 (Drosophila) (HOMER3))
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抗原表位
- AA 155-169, Intracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HOMER3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 原理
- A Rabbit Polyclonal Antibody to Homer3
- 特异性
- Intracellular
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Human - identical, mouse - 14,15 amino acid residues identical
- 产品特性
- Anti-Homer3 Antibody (ABIN7043275, ABIN7045172 and ABIN7045173) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Homer3 from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RSQSADAPGPTERER, corresponding to amino acid residues 155 - 169 of rat Homer3
- 亚型
- IgG
- Top Product
- Discover our top product HOMER3 Primary Antibody
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anti-Homer Homolog 3 (Drosophila) (HOMER3) antibody
HOMER3 适用: 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 281-308) antibodyHOMER3 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB21915 unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (Center) antibodyHOMER3 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 1-177) antibodyHOMER3 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 1-361) antibodyHOMER3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 282-360) antibodyHOMER3 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (pThr36) antibodyHOMER3 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 151-361) antibodyHOMER3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (AA 82-131) antibodyHOMER3 适用: 人, 大鼠, 犬, 马, Cow, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 3 (Drosophila) (HOMER3) (C-Term) antibodyHOMER3 适用: 人, 小鼠, 大鼠, 犬, 马, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:1000
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: (ABIN7235770)
Blocking Peptide: (ABIN7235770)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- HOMER3 (Homer Homolog 3 (Drosophila) (HOMER3))
- 别名
- HOMER3 (HOMER3 产品)
- 背景
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Homer protein homolog 3, Homer scaffold protein 3, VESL3, Homer-3,The HOMER protein family includes Homer1, 2, and 3. These proteins are mainly expressed in the neuronal post-synaptic density (PSD) where they play a role in post-synaptic signaling and receptor trafficking by forming multivalent links with various receptors and PSD scaffolding proteins. The expression level of Homer proteins in non-neural tissues is very low in comparison with that in the nervous system, HOMER3 also expressed in the lung, spleen, kidney and ovary. In the mouse brain HOMER3 is concentrated in the dendritic spines of Purkinje cells connecting the parallel fibers and is also present in their axons, In the hippocampus, HOMER3 is concentrated in the CA2-CA3 regions1,2.All three proteins in the HOMER family have several isoforms as a result of alternative splicing, HOMER3 are shown to exist in both long and short forms, the latter without the C-terminal coiled-coil domains. HOMER3 mRNA is subject to alternative splicing at five different sites giving rise to ten variants of HOMER3 proteins. HOMER1b and HOMER3 have been shown to form a tetramer via the carboxy-terminal domain3.HOMER3 directly binds to type I metabotropic glutamate receptors, which act via phospholipase C to stimulate IP3-mediated release of Ca2+ from intracellular vesicles3.HOMER proteins have also been implicated in axon guidance during brain development4.HOMER3 can regulate transcription and play a very important role in the differentiation and development for some tissues such as muscle and the nervous system. Studies show that HOMER3 abnormal expression plays a role in acute myeloid leukemia (AML). Heterologous expression of HOMER3 in K562 cells inhibits proliferation, influences the cell cycle profile, affects apoptosis and also promotes cell differentiation5.
Alternative names: Homer3, Homer protein homolog 3, Homer scaffold protein 3, VESL3, Homer-3 - 基因ID
- 29548
- NCBI登录号
- NM_001145721
- UniProt
- Q9Z2X5
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