HOMER2 抗体 (C-Term, Intracellular)
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Quick Overview for HOMER2 抗体 (C-Term, Intracellular) (ABIN7043274)
抗原
See all HOMER2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 302-316, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Homer2
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-Homer2 Antibody (ABIN7043274, ABIN7045170 and ABIN7045171) is a highly selective antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Homer2 from human, mouse, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EDKVRSLKTDIEESK, corresponding to amino acid residues 302-316 of rat Homer2
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亚型
- IgG
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anti-Homer Homolog 2 (HOMER2) (AA 1-343) antibody
HOMER2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 2 (HOMER2) (AA 1-343) antibodyHOMER2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Homer Homolog 2 (HOMER2) antibodyHOMER2 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 2 (HOMER2) (AA 1-176) antibodyHOMER2 适用: 大鼠, 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 2 (HOMER2) (AA 1-343) antibodyHOMER2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 2 (HOMER2) (AA 153-202) antibodyHOMER2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235766)
Blocking Peptide: (ABIN7235766)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- HOMER2 (Homer Homolog 2 (HOMER2))
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别名
- HOMER2
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背景
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Synonyms: Homer protein homolog 2, Cupidin, Vesl-2
Description: Homer proteins regulate signal transduction, generation of synapses and receptor trafficking. The homer protein family is comprised of three members with each member alternatively spliced to long and short forms. All members of the Homer family are synaptic scaffolding proteins with an N-terminal EVH (Ena/VASP homology 1) and a C-terminal coiled-coil domain. Long forms of the protein contain both EVH1 and coiled-coil domains and are constitutively expressed, whereas the short forms contain only the EVH1 domain and are expressed in an activity dependent manner1. The Homer family includes three members, Homer1b/c, Homer2a/b, and Homer3. Homer2 protein, also called Vesl-2, is a scaffolding protein that is important for the proper organization, localization and signaling of excitatory postsynaptic receptors. Homer2 protein associates with filamentous actin (F-actin) and directly binds to drebrin, an actin-binding and remodeling protein in dendritic spines. The protein also binds to activated Cdc42, a member of the Rho small GTPase family2. The protein interacts with mGluR1, mGluR5, PI3 Kinase enhancer (PIKE), inositol 1,4,5-trisphosphate receptors (IP3), SHANK and other proteins3,4.Deletion of the Homer2 gene in mice demonstrates several abnormalities in glutamatergic signaling and in the nucleus accumbens such as reduced basal extracellular glutamate content and reduced function and total protein expression of both mGluR1 and the cystine-glutamate exchanger4.
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基因ID
- 29547
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NCBI登录号
- NM_004839
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UniProt
- O88801
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途径
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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