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- 抗原 See all HOMER1 抗体
- HOMER1 (Homer Homolog 1 (HOMER1))
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抗原表位
- AA 293-296, Intracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HOMER1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 原理
- A Rabbit Polyclonal Antibody to Homer1
- 特异性
- Intracellular
- 交叉反应
- 人, 小鼠, 大鼠
- 交叉反应 （详细）
- The antibody will not recognize Homer1 short isoform 3 (also known as Homer1a), but will recognize isoform 2 (also known as Homer1b).
- 预测反应
- Mouse,human - identical
- 产品特性
- Anti-Homer1 Antibody (ABIN7043273, ABIN7045168 and ABIN7045169) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Homer1 from human, mouse, and rat samples. The antibody will not recognize Homer1 short isoform 3 (also known as Homer1a), but will recognize isoform 2 (also known as Homer1b).
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KQEIDNARELQEQR, corresponding to amino acid residues 293-296 of rat Homer1
- 亚型
- IgG
- Top Product
- Discover our top product HOMER1 Primary Antibody
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anti-Homer Homolog 1 (HOMER1) (Center) antibody
HOMER1 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) antibodyHOMER1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 101-150) antibodyHOMER1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, Pig, 猴, Bat, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 96-122), (N-Term) antibodyHOMER1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18229 unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 281-330) antibodyHOMER1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, Pig, 豚鼠, 斑马鱼, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal AT1F3 unconjugated
anti-Homer Homolog 1 (HOMER1) antibodyHOMER1 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400
Application Dilutions Western blot wb: 1:500
- 说明
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Negative Control: (ABIN7235762)
Blocking Peptide: (ABIN7235762)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- HOMER1 (Homer Homolog 1 (HOMER1))
- 别名
- HOMER1 (HOMER1 产品)
- 背景
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Homer protein homolog 1, Homer scaffolding protein 1, Vesl-1, Ves 1, PSD-Zip45, SYN47,Homer proteins regulate signal transduction, generation of synapses and receptor trafficking. The homer protein family is comprised of three members with each member alternatively spliced to long and short forms. All members of the Homer family are synaptic scaffolding proteins with an N-terminal EVH (Ena/VASP homology 1) and a C-terminal coiled-coil domain. Long forms of the protein contain both EVH1 and coiled-coil domains and are constitutively expressed, whereas the short forms contain only the EVH1 domain and are expressed in an activity dependent manner1.The long form of Homer1 assembles group 1 metabotropic glutamate receptors mGluR1 and mGluR5 in large macromolecular complexes at synapses as well as with components of the NMDA receptor complex at the neuronal cell membrane. In contrast, the short form of Homer1 lacks the ability of linking mGluR1/5 to synaptic proteins and functions as an endogenous negative modulator of the mGluR1/5-inositol 1,4,5-trisphosphate receptor signaling complex. Transgenic mice with overexpressed Homer1 in striatal medium spiny neurons demonstrate normal development of striatal structure and afferent/efferent connectivity. However, motor performance in behavioral tasks and striatal responses to the psychomotor stimulant amphetamine are significantly altered in these mice2.At concentrations
Alternative names: Homer1, Homer protein homolog 1, Homer scaffolding protein 1, Vesl-1, Ves 1, PSD-Zip45, SYN47 - 基因ID
- 29546
- NCBI登录号
- NM_004272
- UniProt
- Q9Z214
- 途径
- Skeletal Muscle Fiber Development
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