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- 抗原 See all HRH4 抗体
- HRH4 (Histamine Receptor H4 (HRH4))
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抗原表位
- AA 75-87, Extracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HRH4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Human Histamine H4 Receptor
- 特异性
- 1st extracellular loop
- 预测反应
- Won't recognize rat,mouse H4 Histamine Receptor
- 产品特性
- Anti-Human Histamine H4 Receptor (HRH4) (extracellular) Antibody is directed against an epitope located at the 1st extracellular loop of the human histamine H4 receptor. Anti-Human Histamine H4 Receptor (HRH4) (extracellular) Antibody (ABIN7043272, ABIN7044510 and ABIN7044511)) can be used in western blot and indirect flow cytometry applications, and recognizes H4R from human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: HTLFEWDFGKEIC, corresponding to amino acids 75-87 of human HRH4
- 亚型
- IgG
- Top Product
- Discover our top product HRH4 Primary Antibody
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anti-Histamine Receptor H4 (HRH4) (C-Term) antibody
HRH4 适用: 人 ELISA, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 204-292) antibodyHRH4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (N-Term) antibodyKO Validated HRH4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (Cytoplasmic Domain) antibodyHRH4 适用: 人, 猴 IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 101-200) antibodyHRH4 适用: 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 285-390) antibodyHRH4 适用: 人 WB, ELISA, IF (cc), IHC (p), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) antibodyHRH4 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 359-390), (C-Term) antibodyHRH4 适用: 人 WB 宿主: 兔 Polyclonal RB1073 unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 142-191) antibodyHRH4 适用: 人, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 194-304) antibodyHRH4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:400
- 说明
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Cited Application: IFC
Negative Control: BLP-HR004
Blocking Peptide: BLP-HR004
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- HRH4 (Histamine Receptor H4 (HRH4))
- 别名
- HRH4 (HRH4 产品)
- 背景
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H4R, HH4R, G-protein coupled receptor 105, GPCR105, GPRv53, AXOR35,Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1The biological effects of histamine are mediated through four receptors (H1- H4 receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.Histamine H4 receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, mobilisation of calcium from intracellular stores and activation of the mitogen-activated protein kinase (MAPK) cascade.1,2Histamine H4 receptor is largely expressed in haemopoietic cells including mast cells, eosinophils, dendritic cells and T lymphocytes. H4 receptors modulate eosinophil migration and the selective recruitment of mast cells leading to amplification of histamine-mediated immune responses. In addition, H4 receptors are involved in dendritic cell activation and the regulation of T lymphocyte cytokine production.2,3These studies indicate that histamine H4 receptor is an attractive therapeutic target for the treatment of inflammatory disorders, such as allergy, asthma, chronic pruritus and autoimmune diseases.2,3
Alternative names: Histamine H4 Receptor (HRH4), H4R, HH4R, G-protein coupled receptor 105, GPCR105, GPRv53, AXOR35 - 基因ID
- 59340
- NCBI登录号
- NM_001143828
- UniProt
- Q9H3N8
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