HRH4 抗体 (1st Extracellular Loop)
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Quick Overview for HRH4 抗体 (1st Extracellular Loop) (ABIN7043272)
抗原
See all HRH4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 1st Extracellular Loop
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原理
- A Rabbit Polyclonal Antibody to Human Histamine H4 Receptor
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预测反应
- Won't recognize rat,mouse H4 Histamine Receptor
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产品特性
- Anti-Human Histamine H4 Receptor (HRH4) (extracellular) Antibody is directed against an epitope located at the 1st extracellular loop of the human histamine H4 receptor. Anti-Human Histamine H4 Receptor (HRH4) (extracellular) Antibody (ABIN7043272, ABIN7044510 and ABIN7044511) can be used in western blot and indirect flow cytometry applications, and recognizes H4R from human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- HTLFEWDFGKEIC, corresponding to amino acids 75-87 of human HRH4
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亚型
- IgG
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anti-Histamine Receptor H4 (HRH4) (C-Term) antibody
HRH4 适用: 人 ELISA, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (N-Term) antibodyKO Validated HRH4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 204-292) antibodyHRH4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (Cytoplasmic Domain) antibodyHRH4 适用: 人, 猴 IHC, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 285-390) antibodyHRH4 适用: 人 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 101-200) antibodyHRH4 适用: 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 359-390), (C-Term) antibodyHRH4 适用: 人 WB 宿主: 兔 Polyclonal RB1073 unconjugated
anti-Histamine Receptor H4 (HRH4) antibodyHRH4 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 194-304) antibodyHRH4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H4 (HRH4) (AA 142-191) antibodyHRH4 适用: 人, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- HRH4 (Histamine Receptor H4 (HRH4))
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别名
- HRH4
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背景
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Synonyms: H4R, HH4R, G-protein coupled receptor 105, GPCR105, GPRv53, AXOR35
Description: Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1The biological effects of histamine are mediated through four receptors (H1- H4 receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.Histamine H4 receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, mobilisation of calcium from intracellular stores and activation of the mitogen-activated protein kinase (MAPK) cascade.1,2Histamine H4 receptor is largely expressed in haemopoietic cells including mast cells, eosinophils, dendritic cells and T lymphocytes. H4 receptors modulate eosinophil migration and the selective recruitment of mast cells leading to amplification of histamine-mediated immune responses. In addition, H4 receptors are involved in dendritic cell activation and the regulation of T lymphocyte cytokine production.2,3These studies indicate that histamine H4 receptor is an attractive therapeutic target for the treatment of inflammatory disorders, such as allergy, asthma, chronic pruritus and autoimmune diseases.2,3
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基因ID
- 59340
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NCBI登录号
- NM_001143828
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UniProt
- Q9H3N8
抗原
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