HRH3 抗体 (3rd Intracellular Loop)
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Quick Overview for HRH3 抗体 (3rd Intracellular Loop) (ABIN7043271)
抗原
See all HRH3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 3rd Intracellular Loop
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原理
- A Rabbit Polyclonal Antibody to Histamine H3 Receptor
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human 14,16 amino acid residues identical
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产品特性
- Anti-Histamine H3 Receptor (HRH3) Antibody is directed against an epitope of the rat histamine H3 receptor. Anti-Histamine H3 Receptor (HRH3) Antibody (ABIN7043271 and ABIN7044509) can be used in western blot, immunocytochemistry and immunohistochemistry applications. It has been designed to recognize H3R from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RTRLRLDGGREAGPE, corresponding to amino acids 228-242 of rat HRH3
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亚型
- IgG
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anti-Histamine Receptor H3 (HRH3) (Cytoplasmic Domain) antibody
HRH3 适用: 人, 猴 IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (C-Term) antibodyHRH3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 236-332) antibodyHRH3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 250-350) antibodyHRH3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) antibodyHRH3 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 414-442), (C-Term) antibodyHRH3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01071 unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 121-220) antibodyHRH3 适用: 人, 大鼠 WB, IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 257-359) antibodyHRH3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-Histamine Receptor H3 (HRH3) (Internal Region) antibodyVerified HRH3 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (C-Term) antibodyHRH3 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235758)
Blocking Peptide: (ABIN7235758)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- HRH3 (Histamine Receptor H3 (HRH3))
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别名
- HRH3
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背景
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Synonyms: H3R, HH3R, GPCR97
Description: Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1The biological effects of histamine are mediated through four receptors (H1-H4 receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.H3 receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, activation of the mitogen-activated protein kinase (MAPK) cascade and inhibition of the Na+/H+ exchanger.1,2H3 receptors are expressed primarily in the central nervous system (CNS) where they are located in presynaptic membranes of histaminergic neurons, where they negatively regulate the synthesis and release of histamine. In addition, H3 receptors are also located on nonhistaminergic neurons, where they regulate the release of other amines such as dopamine, serotonin, and norepinephrine.2,3Based on these studies, a central role for H3 receptors has been proposed in disorders involving cognition such as attention deficit and hyperactivity disorder (ADHD), Alzheimer disease and Schizophrenia, as well as sleep and energy homeostasis (i.e. obesity) disorders.2,3
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基因ID
- 85268
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NCBI登录号
- NM_007232
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UniProt
- Q9QYN8
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途径
- cAMP Metabolic Process, Feeding Behaviour
抗原
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