GSG1-Like 抗体 (Intracellular)
Quick Overview for GSG1-Like 抗体 (Intracellular) (ABIN7043266)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 283-295, Intracellular
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原理
- A Rabbit Polyclonal Antibody to GSG1L
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 12,13 amino acid residues identical
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产品特性
- Anti-GSG1L Antibody (ABIN7043266, ABIN7044390 and ABIN7044391) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GSG1L from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CRHERYPTRHQPH, corresponding to amino acid residues 283 - 295 of rat GSG1L
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亚型
- IgG
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anti-GSG1-Like (GSG1L) antibody
GSG1L 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-GSG1-Like (GSG1L) (AA 84-176) antibodyGSG1L 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-GSG1-Like (GSG1L) (AA 232-261), (C-Term) antibodyGSG1L 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33583 unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7235743)
Blocking Peptide: (ABIN7235743)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GSG1-Like (GSG1L)
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别名
- GSG1L
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背景
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Germ cell-specific gene 1-like protein, GSG1-like protein,Germline-specific gene 1-like (GSG1L) is a tetra-spanning membrane protein which belongs to the Claudin protein superfamily. It acts as an auxiliary subunit that modulates the assembly, trafficking and gating of AMPA receptors (AMPAR)1.GSG1L has four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm, the juxtamembrane region in its C-tail extracellular Loop1 domain is critical for its suppression of AMPAR-mediated synaptic transmission2.AMPA receptors are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is involved in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic lateral sclerosis. A newly explored strategy is to manipulate the activity of AMPA receptors is through compounds that affect specific AMPAR-auxiliary subunit complexes. Overexpression of GSG1L strongly suppresses AMPAR, and GSG1L knockout enhances AMPAR-mediated synaptic transmission which makes it a leading therapeutic candidate for manipulating AMPAR activity3.
Alternative names: Germ Cell-Specific Gene 1-Like Protein, GSG1-Like Protein -
基因ID
- 499263
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NCBI登录号
- NM_144675
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UniProt
- D3ZK93
抗原
-
