GRM7 抗体 (Extracellular)
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- 抗原 See all GRM7 抗体
- GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))
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抗原表位
- AA 377-390, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GRM7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Live Cell Imaging (LCI), Immunochromatography (IC), Immunofluorescence (Cultured Cells) (IF (cc))
- 原理
- A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 7
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse,human - identical
- 产品特性
- Anti-mGluR7 (extracellular) Antibody is directed against an extracellular epitope of rat mGluR7. Anti-mGluR7 (extracellular) Antibody (ABIN7043255, ABIN7044346 and ABIN7044347)) can be used in western blot, immunohistochemistry, immunocytochemistry and indirect flow cytometry applications. It has been designed to recognize mGluR7 from human, rat and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: TISGSKKEDTDRKC, corresponding to amino acid residues 377-390 of rat mGluR7
- 亚型
- IgG
- Top Product
- Discover our top product GRM7 Primary Antibody
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anti-Glutamate Receptor, Metabotropic 7 (GRM7) (AA 454-590) antibody
GRM7 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 7G8D3 unconjugated
anti-Glutamate Receptor, Metabotropic 7 (GRM7) (AA 454-590) antibodyGRM7 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 7G8A2 unconjugated
anti-Glutamate Receptor, Metabotropic 7 (GRM7) (Extracellular Domain) antibodyGRM7 适用: 人, 大鼠, 小鼠, 犬, Cow, 兔, 马, 猴, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 7 (GRM7) (N-Term) antibodyGRM7 适用: 人, 大鼠, 小鼠, 犬, Cow, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 7 (GRM7) (N-Term) antibodyGRM7 适用: 人, 大鼠, 小鼠, 犬, Cow, 兔, 马, 猴, 小鸡 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 7 (GRM7) (C-Term) antibodyGRM7 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 7 (GRM7) (C-Term) antibodyGRM7 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 7 (GRM7) (N-Term) antibodyGRM7 适用: 人, Cow WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 7 (GRM7) (C-Term) antibodyGRM7 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 7 (GRM7) (AA 220-410) antibodyGRM7 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: BLP-GC017
Blocking Peptide: BLP-GC017
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))
- 别名
- GRM7 (GRM7 产品)
- 背景
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Metabotropic glutamate receptor 7, GRM7, mGlu7, Gprc1g,Metabotropic glutamate receptors (mGluRs) belong to the super family of G-protein coupled receptors (seven transmembrane proteins). mGluRs are further divided into subfamilies: group I mGluRs (mGluR1 and mGluR5) which couple to Gq, thereby activating phospholipase C (PLC). Group II which include mGluR2 and mGluR3 couple to Gi, therefore inhibit the formation of adenylate cyclase. mGluR4, 6, 7, 8 which belong to group III also inhibit adenylate cyclase formation by coupling to Gi1.The C-terminus of these receptors has important functions in modulating their activity. This region is important for G-protein coupling, post-translational modifications like phosphorylation as well as protein-protein interactions. The C-terminal region is also subject to alternative splicing2. Indeed, mGluR7 can be detected as five different splice variants3.Like all group III metabotropic glutamate receptors, mGluR7 is localized presynaptically. It is highly expressed in the central nervous system and could also be detected in some peripheral organs like hair cells and spiral ganglion cells of the inner ear3.As opposed to other group III metabotropic glutamate receptors, mGluR7 has very low affinity for its substrate L-glutamate, therefore, only under high synaptic activity is the receptor active. This enables the receptor to act as a negative feedback loop by inhibiting the release of L-glutamate3,4.mGluR7 may play a molecular role in the pathways leading to emotion and cognition4.
Alternative names: mGluR7, Metabotropic glutamate receptor 7, GRM7, mGlu7, Gprc1g - 基因ID
- 81672
- NCBI登录号
- NM_000844
- UniProt
- P35400
- 途径
- Sensory Perception of Sound, cAMP Metabolic Process, Feeding Behaviour
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